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首页> 外文期刊>ACS applied materials & interfaces >Dual-Functionalized Janus Mesoporous Silica Nanoparticles with Active Targeting and Charge Reversal for Synergistic Tumor-Targeting Therapy
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Dual-Functionalized Janus Mesoporous Silica Nanoparticles with Active Targeting and Charge Reversal for Synergistic Tumor-Targeting Therapy

机译：双官能化Janus中孔二氧化硅纳米粒子，具有活性靶向和电荷反转，用于协同肿瘤靶向治疗

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摘要

Janus nanoparticles with an anisotropic feature concentrated multiple properties on a single carrier, providing synergistic effects. In this study, dual-functionalized Janus nanoparticles (HA-JMSN/DOX-DMMA) were constructed with a tumor-targeting ligand (hyaluronic acid, HA) modified on the one side and a charge reversal group (2,3-dimethylmaleic anhydride, DMMA) on the other side. The drug release of HA-JMSN/DOX-DMMA was positively correlated with the acidity of the environment. The cytotoxicity and cell uptake of HA-JMSN/DOX-DMMA were superior to the isotropous nanoparticles. The endocytosis pathway of HA-JMSN/DOX-DMMA involved the clathrin-mediated endocytosis (HA) and the micropinocytosis (DMMA) at the same time, which indicated that they both participated in the interaction between nanoparticles and tumor cells. After being injected intravenously in mice, the distribution of HA-JMSN/DOX-DMMA in tumor was enhanced significantly. The antitumor therapy study in vivo showed that HA-JMSN/DOX-DMMA inhibited tumor growth and improved the survival rate of tumor-bearing mice effectively. In general, HA-JMSN/DOX-DMMA could take the synergistic effect of active targeting and charge reversal to deliver drug in tumor cells and kill them efficiently, which was a promising antitumor nanodrug.
机译：Janus纳米颗粒具有各向异性特征在单个载体上浓缩多种性质，提供协同效应。在该研究中，用肿瘤靶向配体（透明质酸，HA）构建双官能化Janus纳米颗粒（HA-JMSN / DOX-DMMA）在一侧和电荷反转基团（2,3-二甲基MaliC酸酐， DMMA）在另一边。 HA-JMSN / DOX-DMMA的药物释放与环境的酸度正相关。 HA-JMSN / DOX-DMMA的细胞毒性和细胞吸收优于各等渗纳米颗粒。 HA-JMSN / DOX-DMMA的内吞作用涉及同时克拉仑介导的内吞作用（HA）和微生物细胞增生（DMMA），表明它们均参与纳米颗粒和肿瘤细胞之间的相互作用。在静脉内注射小鼠后，肿瘤中HA-JMSN / DOX-DMMA的分布显着提高。体内抗肿瘤治疗研究表明，HA-JMSN / DOX-DMMA抑制肿瘤生长，从而有效地提高了肿瘤小鼠的存活率。通常，HA-JMSN / DOX-DMMA可以采取活性靶向和电荷逆转的协同效应，以递送肿瘤细胞中的药物，有效地杀死它们，这是一个有前途的抗肿瘤纳米芽树。

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