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首页> 外文期刊>ACS applied materials & interfaces >Biocompatible Croconaine Aggregates with Strong 1.2-1.3 mu m Absorption for NIR-IIa Photoacoustic Imaging in Vivo
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Biocompatible Croconaine Aggregates with Strong 1.2-1.3 mu m Absorption for NIR-IIa Photoacoustic Imaging in Vivo

机译：生物相容性的冰氧聚集在体内尼尔 - IIA光声成像的强度为1.2-1.3μm

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摘要

Although photoacoustic imaging (PAI) in the second near-infrared (NIR-II) region (1.0-1.7 mu m) is admired for deeper penetration and higher contrast, few organic NIR-II absorbers are available as exogenous contrast agents in vivo. A1094 belongs to the very few similar to 1.1 mu m absorbing croconaine dyes that have superior extinction coefficient and tend to form irregular aggregation. In this study, shape-controlled A1094@ DSPE-PEG(2000) micelles with a J-aggregate core with remarkable 1.2-1.3 mu m absorption are fabricated as biocompatible organic agents. Excellent capabilities in photothermal conversion, photostability, and PAI are found in in vitro studies. In vivo PAI of inguinal lymph nodes and in situ glioma pre- and post-resection, all demonstrate high lymph/tumor-targeting efficiency. An similar to 4.54 mm deep brain lesion is imaged at 1200 nm with minimized background and increased contrast compared to 970 nm. Overall, we achieved significant bathochromic shift of organic absorbers and expanded their PAI application to the long-wavelength end of the NIR-IIa region.
机译：尽管在第二近红外（NIR-II）区域（1.0-1.7μm）中的光声成像（PAI）被钦佩深入渗透和更高的对比度，但很少有机NIR-II吸收剂可作为体内外源性造影剂提供。 A1094属于吸收具有优异消光系数的冰氧染料的少数类似于1.1慕的染料，并且倾向于形成不规则的聚集。在该研究中，使用具有显着的1.2-1.3μm的J-骨料芯的形状控制的A1094 @ DSPE-PEG（2000）胶束作为生物相容性有机剂制备。在体外研究中发现了光热转换，光稳定性和PAI的优异能力。在腹股沟淋巴结的体内淋巴结和原位胶质瘤前和切除后，全部表现出高淋巴/肿瘤靶向效率。与4.54毫米的深脑病变相似，在1200nm下成像，与970nm相比，最小化的背景和增加对比度。总体而言，我们实现了有机吸收剂的显着的玄神变化，并将其PAI应用扩展到NIR-IIA区域的长波长末端。

著录项

  • 来源
    《ACS applied materials & interfaces》 |2019年第34期|共7页
  • 作者

    Liu Huanhuan; Wang Xiangyu; Huang Yanfang; Li Honghui; Peng Chenyu; Yang Hongzhang; Li Jindian; Hong Huawei; Lei Zhao; Zhang Xiaofen; Li Zijing;

  • 作者单位

    Xiamen Univ State Key Lab Mol Vaccinol &

    Mol Diagnost Ctr Mol Imaging &

    Translat Med Sch Publ Hlth Xiamen 361102 Fujian Peoples R China;

    Xiamen Univ State Key Lab Mol Vaccinol &

    Mol Diagnost Ctr Mol Imaging &

    Translat Med Sch Publ Hlth Xiamen 361102 Fujian Peoples R China;

    Xiamen Univ State Key Lab Mol Vaccinol &

    Mol Diagnost Ctr Mol Imaging &

    Translat Med Sch Publ Hlth Xiamen 361102 Fujian Peoples R China;

    Xiamen Univ State Key Lab Mol Vaccinol &

    Mol Diagnost Sch Publ Hlth Xiamen 361102 Fujian Peoples R China;

    Xiamen Univ State Key Lab Mol Vaccinol &

    Mol Diagnost Ctr Mol Imaging &

    Translat Med Sch Publ Hlth Xiamen 361102 Fujian Peoples R China;

    Xiamen Univ State Key Lab Mol Vaccinol &

    Mol Diagnost Ctr Mol Imaging &

    Translat Med Sch Publ Hlth Xiamen 361102 Fujian Peoples R China;

    Xiamen Univ State Key Lab Mol Vaccinol &

    Mol Diagnost Ctr Mol Imaging &

    Translat Med Sch Publ Hlth Xiamen 361102 Fujian Peoples R China;

    Xiamen Univ State Key Lab Mol Vaccinol &

    Mol Diagnost Ctr Mol Imaging &

    Translat Med Sch Publ Hlth Xiamen 361102 Fujian Peoples R China;

    Xiamen Univ State Key Lab Mol Vaccinol &

    Mol Diagnost Sch Publ Hlth Xiamen 361102 Fujian Peoples R China;

    Xiamen Univ State Key Lab Mol Vaccinol &

    Mol Diagnost Sch Publ Hlth Xiamen 361102 Fujian Peoples R China;

    Xiamen Univ State Key Lab Mol Vaccinol &

    Mol Diagnost Ctr Mol Imaging &

    Translat Med Sch Publ Hlth Xiamen 361102 Fujian Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    croconaine dye; the second near-infrared window; micelle; J-aggregation; photoacoustic imaging;

    机译：Croconaine染料;第二个近红外窗口;胶束;J-聚集;光声成像;

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