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首页> 外文期刊>ACS applied materials & interfaces >Multilayer Ag-Embedded Silica Nanostructure as a Surface-Enhanced Raman Scattering-Based Chemical Sensor with Dual-Function Internal Standards
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Multilayer Ag-Embedded Silica Nanostructure as a Surface-Enhanced Raman Scattering-Based Chemical Sensor with Dual-Function Internal Standards

机译：多层Ag嵌入式二氧化硅纳米结构作为表面增强拉曼散射的化学传感器，具有双功能内标

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摘要

Surface-enhanced Raman scattering (SERS) spectroscopy is attractive in various detection analysis fields. However, the quantitative method using SERS spectroscopy remains as an area to be developed. The key issues in developing quantitative analysis methods by using SERS spectroscopy are the fabrication of reliable SERS-active materials such as nanoparticle-based structures and the acquisition of the SERS signal without any disturbance that may change the SERS signal intensity and frequency. Here, the fabrication of seamless multilayered core-shell nanoparticles with an embedded Raman label compound as an internal standard (MLRLC dots) for quantitative SERS analysis is reported. The embedded Raman label compound in the nanostructure provides a reference value for calibrating the SERS signals. By using the MLRLC dots, it is possible to gain target analyte signals of different concentrations while retaining the Raman signal of the internal standard. The ML4-BBT dots, containing 4-bromobenzenethiol (4-BBT) as an internal standard, are successfully applied in the quantitative analysis of 4-fluorobenzenethiol and thiram, a model pesticide. Additionally, ratiometric analysis was proved practical through normalization of the relative SERS intensity. The ratiometric strategy could be applied to various SERS substrates for quantitative detection of a wide variety of targets.
机译：表面增强拉曼散射（SERS）光谱在各种检测分析领域具有吸引力。然而，使用SERS光谱的定量方法保持为要开发的区域。通过使用SERS光谱来开发定量分析方法的关键问题是制造可靠的SERS-活性材料，例如基于纳米粒子的结构和SERS信号，而没有任何可能改变SERS信号强度和频率的干扰。这里，报道了具有嵌入式拉曼标签化合物作为用于定量SERs分析的内标（MLRLC点）的无缝多层核 - 壳纳米颗粒的制造。纳米结构中的嵌入拉曼标签化合物提供了用于校准SERS信号的参考值。通过使用MLRLC点，可以在保持内标的拉曼信号的同时获得不同浓度的目标分析物信号。含有4-溴苯硫醇（4-BBT）作为内标的ML4-BBT点，成功地应用于4-氟苯硫醇和王子，模型农药。另外，通过相对SERS强度的标准化证明了比例分析。可以将比率策略应用于各种SERS基材，用于定量检测各种靶标。

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