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首页> 外文期刊>ACS applied materials & interfaces >Supramolecular Chemotherapy: Carboxylated Pillar[6]arene for Decreasing Cytotoxicity of Oxaliplatin to Normal Cells and Improving Its Anticancer Bioactivity Against Colorectal Cancer
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Supramolecular Chemotherapy: Carboxylated Pillar[6]arene for Decreasing Cytotoxicity of Oxaliplatin to Normal Cells and Improving Its Anticancer Bioactivity Against Colorectal Cancer

机译：超分子化疗：羧化柱[6]芳烃用于将奥沙利铂的细胞毒性降低到正常细胞，并改善其抗癌性癌症的抗癌性生物活性

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摘要

We have successfully demonstrated that the lost guest complex of carboxylated pillar[6]arene with oxaliplatin (OxPt) exhibits low cytotoxicity toward normal tells and displays higher anticancer bioactivity against "colorectal cancer cells than OxPt itself. Owing to higher -binding affinity of carboxylated pillar[6]arene with spermine-(SPM) than that with-OxPt, the encapsulated OxPt can be thoroughly released frOm its host guest tornplex by the competitive-replacement with SPM. This supramolecular, chemotherapy works well both in vitro and in vivo for SPM;overexpressed cancers, such as colorectal cancer. Compared to OxPt itself, the anticancer bioactivity of this host guest complex is further improved by about 20%. Such an improvement results from: the combined effect of controlled release of OxPt from its host guest complex and simultaneous consumption of SPM by carboxylated pillar[6]arene. It is anticipated' that this supramolecular strategy may be extended to other clinical anticancer drugs for decrearsingtheir severe side effects and improving their anticancer bioactivity, thus enriching the realm of supramolecular chemotherapy.
机译：我们已成功证明羧基化柱[6]芳烃与Oxaliplatin（OXPT）的丢失的客房复合物对正常的表现出低细胞毒性，并表现出对“结肠直肠癌细胞的抗癌性生物活性比oxpt本身”。由于羧化柱的更高措施较高的亲和力[6]芳烃与用oxpt的精子 - （spm），封装的oxpt可以通过与spm的竞争置换液从其主人替换彻底释放。这种超分子，化疗均在体外和体内均用于SPM ;过表达癌症，如结肠直肠癌。与OXPT本身相比，这位寄主嘉宾复合物的抗癌生物活性进一步提高了约20％。这种改进结果来自：来自其主人复杂的奥运区控释释放的综合影响通过羧化柱的同时消耗SPM [6]芳烃。预期'该超分子策略可能会扩展到其他临床抗病R药物用于逐次副作用的逐次效应和改善抗癌性生物活性，从而富有超分子化疗的境界。

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