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首页> 外文期刊>ACS applied materials & interfaces >Activating TiO2 Nanoparticles: Gallium-68 Serves as a High-Yield Photon Emitter for Cerenkov-Induced Photodynamic Therapy
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Activating TiO2 Nanoparticles: Gallium-68 Serves as a High-Yield Photon Emitter for Cerenkov-Induced Photodynamic Therapy

机译：激活TiO2纳米颗粒：镓-68用作Cerenkov诱导的光动力治疗的高产光子发射器

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摘要

The classical photodynamic therapy (PDT) requires external light to activate photosensitizers for cancer treatment. However, limited tissue penetration of light has been a long-standing challenge for PDT to cure malignant tumors in deep tissues. Recently, Cerenkov radiation (CR) emitted by radiotracers such as BFfluorodeoxyglucose (18F-FDG) has become an alternative and promising internal light source. Nevertheless, fluorine-18 (F-18) only releases 1.3 photons per decay in average; consequently, injection dose of F-18 goes beyond 10-30 times more than usual to acquire therapeutic efficacy because of its low Cerenkov productivity. Gallium 68 (Ga-68) is a favorable CR source owing to its ready availability from generator and 30-time higher Cerenkov productivity. Herein, we report, for the first time, the use of Ga-68 as a CR source to activate dextran-modified TiO2 nanoparticles (D-TiO2 NPs) for CR-induced PDT. Compared with '8F-FDG, 68Ga-labeled bovine serum albumin (68Ga-BSA) inhibited the growth of 4T1 cells and exhibited significantly stronger DNA damage to tumor cells. In vivo studies showed that the tumor growth was almost completely inhibited when tumor-bearing mice were treated with a combination of D-TiO2 NPs and 68Ga-BSA. This study proved that Ga-68 is a more potent radionuclide for PDT than F-18 both in vitro and in vivo offered a promising strategy of using a diagnostic dose of radioactivity to achieve depth-independent cancer therapy without using any external light source.
机译：经典光动力治疗（PDT）需要外部光来激活光敏剂以进行癌症治疗。然而，Light的组织渗透是PDT治疗深层组织中恶性肿瘤的长期挑战。最近，诸如BfforodoOx亚谷葡萄糖（18F-FDG）之类的放射体制物（如Bufforodoxyglucose（18F-FDG）发出的Cerenkov辐射（Cr）已成为替代和有前途的内部光源。然而，氟-18（F-18）平均仅释放1.3个光子;因此，由于其低CERENKOV生产率，F-18的注射剂量比平常更高超过10-30倍以获得治疗效果。镓68（GA-68）由于其现成的发电机和30次更高的Cerenkov生产力而言，这是一个有利的CR来源。在此，我们首次报告Ga-68作为Cr源以激活用于Cr诱导的PDT的葡聚糖改性的TiO2纳米颗粒（D-TiO 2 NP）。与'8F-FDG相比，68GA标记的牛血清白蛋白（68GA-BSA）抑制了4T1细胞的生长，对肿瘤细胞造成显着更强的DNA损伤。在体内研究表明，当用D-TiO2 NPS和68Ga-BSA的组合处理携带肿瘤小鼠时，肿瘤生长几乎完全抑制。该研究证明，GA-68是PDT的富含效率的放射性核素，其在体外和体内既比F-18都提供了使用诊断剂量放射性的有希望的策略，而不使用任何外部光源。

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    Duan Dongban; Liu Hui; Xu Yang; Han Yuxiang; Xu Mengxin; Zhang Zhengchu; Liu Zhibo;

  • 作者单位

    Peking Univ Coll Chem &

    Mol Engn Radiochem &

    Radiat Chem Key Lab Fundamental Sci Beijing Natl Lab Mol Sci Beijing 100871 Peoples R China;

    Peking Univ Coll Chem &

    Mol Engn Radiochem &

    Radiat Chem Key Lab Fundamental Sci Beijing Natl Lab Mol Sci Beijing 100871 Peoples R China;

    Peking Univ Coll Chem &

    Mol Engn Radiochem &

    Radiat Chem Key Lab Fundamental Sci Beijing Natl Lab Mol Sci Beijing 100871 Peoples R China;

    Peking Univ Coll Chem &

    Mol Engn Radiochem &

    Radiat Chem Key Lab Fundamental Sci Beijing Natl Lab Mol Sci Beijing 100871 Peoples R China;

    Peking Univ Coll Chem &

    Mol Engn Radiochem &

    Radiat Chem Key Lab Fundamental Sci Beijing Natl Lab Mol Sci Beijing 100871 Peoples R China;

    Peking Univ Coll Chem &

    Mol Engn Radiochem &

    Radiat Chem Key Lab Fundamental Sci Beijing Natl Lab Mol Sci Beijing 100871 Peoples R China;

    Peking Univ Coll Chem &

    Mol Engn Radiochem &

    Radiat Chem Key Lab Fundamental Sci Beijing Natl Lab Mol Sci Beijing 100871 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    Cerenkov radiation; photodynamic therapy; titanium dioxide; Gallium-68; positron emission tomography;

    机译：Cerenkov辐射;光动力疗法;二氧化钛;镓-68;正电子发射断层扫描;

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