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首页> 外文期刊>ACS applied materials & interfaces >Novel Alkali Activation of Titanium Substrates To Grow Thick and Covalently Bound PMMA Layers
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Novel Alkali Activation of Titanium Substrates To Grow Thick and Covalently Bound PMMA Layers

机译：钛基材的新型碱活化生长厚，共价结合的PMMA层

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Titanium (Ti) is the most widely used metal in biomedical applications because of its biocompatibility; however, the significant difference in the mechanical properties between Ti and the surrounding tissues results in stress shielding which is detrimental for load-bearing tissues. In the current study, to attenuate the stress shielding effect, a new processing route was developed. It aimed at growing thick poly(methyl methacrylate) (PMMA) layers grafted on Ti substrates to incorporate a polymer component on Ti implants. However, the currently available methods do not allow the development of thick polymeric layers, reducing significantly their potential uses. The proposed route consists of an alkali activation of Ti substrates followed by a surface-initiated atom transfer radical polymerization using a phosphonic acid derivative as a coupling agent and a polymerization initiator and malononitrile as a polymerization activator. The average thickness of the grown PMMA layers is approximately 1.9 mu m. The Ti activation-performed in a NaOH solution-leads to a porous sodium titanate interlayer with a hierarchical structure and an open microporosity. It promotes the covalent grafting reaction because of high hydroxyl groups content and enables establishing a further mechanical interlocking between the growing PMMA layer and the Ti substrate. As a result, the produced graduated structure possesses high Ti/PMMA adhesion strength (similar to 260 MPa). Moreover, the PMMA layer is (i) thicker compared to those obtained with the previously reported techniques (similar to 1.9 mu m), (ii) stable in a simulated body fluid solution, and (iii) biocompatible. This strategy opens new opportunities toward hybrid prosthesis with adjustable mechanical properties with respect to host bone properties for personalized medicines.
机译：由于其生物相容性，钛（TI）是生物医学应用中最广泛使用的金属;然而，Ti和周围组织之间的机械性能的显着差异导致应力屏蔽，这是对承载组织有害的应力屏蔽。在目前的研究中，为了衰减应力屏蔽效果，开发了一种新的加工路线。旨在植入于Ti底物上的厚聚（甲基丙烯酸甲酯）（PMMA）层以掺入Ti植入物上的聚合物组分。然而，目前可用的方法不允许开发厚聚合物层，从而显着降低它们的潜在用途。所提出的途径由Ti底物的碱活化组成，然后使用膦酸衍生物作为偶联剂和聚合引发剂和丙二腈作为聚合活化剂的膦酸衍生物进行自由基聚合。生长的PMMA层的平均厚度约为1.9μm。 Ti活化 - 在NaOH溶液中进行 - 导致具有分层结构和开放微孔的多孔钛酸钠中间层。它促进了由于高羟基含量的共价接枝反应，并且能够在生长的PMMA层和Ti衬底之间建立进一步的机械互锁。结果，产生的刻度结构具有高Ti / PMMA粘附强度（类似于260MPa）。此外，与用先前所报道的技术（类似于1.9μm），（ii）在模拟体液溶液中稳定的那些（III）生物相容性相比，PMMA层是厚的。该策略为杂交假体开辟了具有可调节机械性能的杂交假体的机会，用于个性化药物的宿主骨骼性能。

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