...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>ACS applied materials & interfaces >Silver-Coated Colloidosomes as Carriers for an Anticancer Drug
【24h】

Silver-Coated Colloidosomes as Carriers for an Anticancer Drug

机译：银涂层胶体胶囊作为抗癌药物的载体

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Small drug molecules are widely developed and used in the pharmaceutical industry. In the past few years, loading and delivering such molecules using polymer-shell colloidosomes has attracted interest. Traditional polymer capsules fail to encapsulate low-molecular-weight materials for long times, since they are inherently porous and permeable for small molecules. In this paper, we report a method for encapsulating an anticancer drug, with small molecule weight, for cell viability tests. The silver-coated colloidosomes are prepared by making an aqueous core capsule with a polymer shell and then adding AgNO3, surfactant, and L-ascorbic acid to form a second shell. The capsulesare impermeable and,. can be triggered using ultrasound. We propose to use the capsules as drug carriers. The:silver demonstrates a low cytotoxicity for up to 10:capsules per Cell. After the silver shells are triggered by ultrasound, the released doxorubicin, the broken silver fragments and the doxorubicin loading, On the capsule surface all kill cells. The results demonstrate a nonpermeable silver-shell microcapsule with ultrasound sensitivity for potential medical applications.
机译：小药物分子广泛开发并用于制药行业。在过去的几年中，使用聚合物 - 壳胶体体加载和递送这些分子引起了利益。传统的聚合物胶囊未能长时间封装低分子量材料，因为它们本质上对小分子具有多孔且渗透性。在本文中，我们报告了一种用于将抗癌药物包封的方法，用于细胞活力测试。通过用聚合物壳制备含水芯胶囊，然后加入AgNO 3，表面活性剂和L-抗坏血酸以形成第二壳，制备银涂覆的胶体体。胶囊不透水，。可以使用超声触发。我们建议将胶囊用作药物载体。 ：银证明每种细胞最多10种以下的细胞毒性。通过超声波触发银壳后，释放的多柔比星，破碎的银片和多柔比蛋白负载，胶囊表面上所有杀死细胞。结果表明，具有超声敏感性的可逆性银壳微胶囊，用于潜在的医疗应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号