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首页> 外文期刊>American Journal of Physiology >Electromechanical wavebreak in a model of the human left ventricle.
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Electromechanical wavebreak in a model of the human left ventricle.

机译：在人左心室的模型中的机电波浪。

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In the present report, we introduce an integrative three-dimensional electromechanical model of the left ventricle of the human heart. Electrical activity is represented by the ionic TP06 model for human cardiac cells, and mechanical activity is represented by the Niederer-Hunter-Smith active contractile tension model and the exponential Guccione passive elasticity model. These models were embedded into an anatomic model of the left ventricle that contains a detailed description of cardiac geometry and the fiber orientation field. We demonstrated that fiber shortening and wall thickening during normal excitation were qualitatively similar to experimental recordings. We used this model to study the effect of mechanoelectrical feedback via stretch-activated channels on the stability of reentrant wave excitation. We found that mechanoelectrical feedback can induce the deterioration of an otherwise stable spiral wave into turbulent wave patterns similar to that of ventricular fibrillation. We identified the mechanisms of this transition and studied the three-dimensional organization of this mechanically induced ventricular fibrillation.
机译：在本报告中，我们介绍了人类左心室的一体化三维机电模型。电活性由IONIC TP06模型代表人类心脏细胞，并且机械活性由Niederer-Hunter-Smith有源收缩张力模型和指数Guccione被动弹性模型代表。将这些模型嵌入到左心室的解剖模型中，该模型包含心脏几何形状和纤维取向场的详细描述。我们证明，正常励磁期间的纤维缩短和壁厚与实验记录具有定性类似。我们利用该模型来研究通过拉伸激活通道的机械光反馈对旋回波激发稳定性的影响。我们发现，机械电反馈可以引起诸如稳定的螺旋波的劣化，与湍流波模式类似于与心室颤动的湍流波纹。我们确定了这种转变的机制，并研究了这种机械诱导的心室颤动的三维组织。

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