JTZ-951, an HIF prolyl hydroxylase inhibitor, suppresses renal interstitial fibroblast transformation and expression of fibrosis-related factors

Takeshi Wakashima; Tetsuhiro Tanaka; Kenji Fukui; Yasumasa Komoda; Yuichi Shinozaki; Hatsue Kobayashi; Akira Matsuo; Masaomi Nangaku

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JTZ-951, an HIF prolyl hydroxylase inhibitor, suppresses renal interstitial fibroblast transformation and expression of fibrosis-related factors

机译：JTZ-951，HIF脯氨酰羟化酶抑制剂，抑制肾间质成纤维细胞转化和纤维化相关因素的表达

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Tubular interstitial fibrosis (TIF) is a major hallmark of chronic kidney disease (CKD). TIF has been considered an important therapeutic target for CKD because of a well-established correlation between TIF and kidney function (5). Although many efforts have been made to develop effective treatments for TIF, these efforts have not been successful so far.

机译：管状间质纤维化（TIF）是慢性肾病（CKD）的主要标志。由于TIF和肾功能（5）之间具有良好的相关性，TIF被认为是CKD的重要治疗靶标。虽然已经做出了许多努力，为TIF制定有效的治疗，但这些努力到目前为止还没有成功。

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来源
《American Journal of Physiology》 |2020年第2期|共11页
作者
Takeshi Wakashima; Tetsuhiro Tanaka; Kenji Fukui; Yasumasa Komoda; Yuichi Shinozaki; Hatsue Kobayashi; Akira Matsuo; Masaomi Nangaku;
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Division of Nephrology and Endocrinology The University of Tokyo Graduate School of Medicine;

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正文语种 eng
中图分类人体生理学;
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专利

1. JTZ-951, an HIF prolyl hydroxylase inhibitor, suppresses renal interstitial fibroblast transformation and expression of fibrosis-related factors [J] . Takeshi Wakashima, Tetsuhiro Tanaka, Kenji Fukui, American Journal of Physiology . 2020,第1aPta2期

机译：JTZ-951，HIF脯氨酰羟化酶抑制剂，抑制肾间质成纤维细胞转化和纤维化相关因素的表达
2. Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia [J] . Yosuke Ogoshi, Takuya Matsui, Ikuo Mitani, ACS medicinal chemistry letters . 2017,第12期

机译：JTZ-951的发现：一种用于治疗肾性贫血的HIF脯氨酰羟化酶抑制剂
3. Hypoxia-inducible factor (HIF)-independent expression mechanism and novel function of HIF prolyl hydroxylase-3 in renal cell carcinoma [J] . TanakaT., TorigoeT., HirohashiY., Journal of Cancer Research and Clinical Oncology . 2014,第3期

机译：缺氧诱导因子（HIF）依赖性表达机制和HIF脯氨酰羟化酶3在肾细胞癌中的新功能
4. Hypoxia-lnducible Factor-Prolyl Hydroxylase Domain Inhibitors to Treat Anemia in Chronic Kidney Disease [C] . Midori Sakashita, Tetsuhiro Tanaka, Masaomi Nangaku Nihon To?seki Igakkai., Gakujutsu Shu?kai So?kai . 2019

机译：缺氧诱导因子 - 羟基羟化酶结构域抑制剂治疗慢性肾病贫血
5. Regulation of the proapoptotic protein BIM-EL through its interactions with the tumor suppressor pVHL and the HIF prolyl hydroxylase EGLN3 [D] . Guo, Yanan. 2008

机译：通过与肿瘤抑制因子pVHL和HIF脯氨酰羟化酶EGLN3相互作用来调节凋亡蛋白BIM-EL
6. Ang-1 Gene Therapy Inhibits Hypoxia-Inducible Factor-1α (HIF-1α)-Prolyl-4-Hydroxylase-2 Stabilizes HIF-1α Expression and Normalizes Immature Vasculature in db/db Mice [O] . Jian-Xiong Chen, Amanda Stinnett 2008

机译：Ang-1基因疗法抑制缺氧诱导因子-1α（HIF-1α）-脯氨酰-4-羟化酶-2稳定HIF-1α表达并使db / db小鼠的未成熟脉管正常化。
7. Ang-1 Gene Therapy Inhibits Hypoxia-Inducible Factor-1α (HIF-1α)-Prolyl-4-Hydroxylase-2, Stabilizes HIF-1α Expression, and Normalizes Immature Vasculature in db/db Mice [O] . Chen, Jian-Xiong, Stinnett, Amanda 2008

机译：Ang-1基因疗法抑制缺氧诱导因子-1α（HIF-1α）-脯氨酰-4-羟化酶-2，稳定HIF-1α表达，并使db / db小鼠的未成熟脉管正常化。

JTZ-951, an HIF prolyl hydroxylase inhibitor, suppresses renal interstitial fibroblast transformation and expression of fibrosis-related factors

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