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首页> 外文期刊>American Journal of Physiology >Role of glucocorticoid signaling in exercise-associated changes in high-fat diet preference in rats
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Role of glucocorticoid signaling in exercise-associated changes in high-fat diet preference in rats

机译：糖皮质激素信号传导在大鼠高脂饮食偏好中的运动相关变化中的作用

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The inability to adapt to chronic stress is associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and hypersecretion of adrenal hormones, which increases abdominal obesity and promotes the development of metabolic syndrome (9, 20, 68). Maladaptive stress responses also increase an individual's potential to develop disordered eating behavior such as binge and "stress eating" of highly palatable,energy dense comfort food (3, 15, 20). Regular physical activity can alleviate stress-related psychopathologies and facilitate energy balance. Using a simultaneous two-diet choice (high-carbohydrate chow vs. high-fat diet) and voluntary wheel running (WR) rat model, we have shown that WR reduces high-fat (HF) diet intake and preference to the extent of complete avoidance in males (46). In a subsequent study with both male and female rats, we found that the majority of males persistently avoid HF diet whereas the majority of females increase HF diet intake and subsequently develop HF diet preference (91). Ovariectomy does not completely eliminate sex differences and orchiectomy does not affect HF diet avoidance in male running rats (91). Thus, the central neurobiolog-ical mechanisms underlying running-associated HF diet avoidance and sex differences in this behavior remain unclear.
机译：无法适应慢性应激与肝炎 - 垂体 - 肾上腺（HPA）轴的失调与肾上腺激素的过度，这增加了腹部肥胖并促进代谢综合征（9,2,68）的发育。适应不良压力反应也增加了个体的潜力，这些潜力可以发展饮食行为，如狂欢和“压力进食”的高度可口，能量密集的舒适食品（3,15,20）。定期体育活动可以缓解相关的强加的精神病理学并促进能量平衡。使用同时的两饮食选择（高碳水化合物周和高脂饮食）和自愿车轮运行（WR）大鼠模型，我们已经表明WR减少了高脂肪（HF）饮食摄入和偏好到完整的程度在男性中避免（46）。在随后与男性和女性大鼠的研究中，我们发现大多数男性持续避免了HF饮食，而大多数女性增加了HF饮食摄入量，随后发展HF饮食偏好（91）。卵巢切除术并不完全消除性差异，睾丸切除术不影响男性运行大鼠（91）中的HF饮食。因此，在这种行为中循环相关的HF饮食避免和性差异的中央神经疾病机制仍不清楚。

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