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首页> 外文期刊>American Journal of Physiology >Deficiency of intramuscular ICC increases fundic muscle excitability but does not impede nitrergic innervation
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Deficiency of intramuscular ICC increases fundic muscle excitability but does not impede nitrergic innervation

机译：肌肉内ICC的缺乏增加了基础肌肉兴奋性，但不妨碍氮气性的内脏

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First published December 20, 2007; doi:10.1152/ajpgi.00130.2007.-The motility of the gastrointestinal tract is generated by smooth muscle cells and is controlled to a large extent by an intrinsic neural network. A gap of -200 nm usually separates nerve varicosities from smooth muscle cells, which suggests that direct innervation of the smooth muscle by synapses does not occur. Enteric nerves do make synapse-like contact with proposed regulatory cells, the interstitial cells of Cajal (ICC), which in turn may be in gap junction contact with smooth muscle cells. The role played by ICC in enteric innervation is controversial. Experimental evidence has been presented in vitro for the hypothesis that nitrergic inhibitory innervation is strongly reduced in the absence of ICC, However, in vivo data appear to dispute that. The present report provides evidence that explains the discrepancy between in vivo and in vitro data and provides evidence that inhibitory neurotransmitters can reach smooth muscle cells without hindrance when ICC are absent. The fundic musculature shows increased responses to substance P-mediated innervation and shows marked spontaneous activity, which is consistent with increased muscle excitability.
机译：2007年12月20日第一次出版; DOI：10.1152 / AJPGI.00130.2007 - 胃肠道的动力由平滑肌细胞产生，并通过内在神经网络在很大程度上控制。 -200nm的间隙通常将神经含有神经含有从平滑肌细胞分离，这表明不会发生突触的平滑肌的直接支配。肠道神经确实使突触状接触与所提出的调节细胞，CAJAL（ICC）的间质细胞，这又可以是与平滑肌细胞的间隙结接触。 ICC在肠道内接管中扮演的作用是有争议的。实验证据已经在体外提出了假设，即在没有ICC的情况下强烈减少氮气性抑制的内核，然而，体内数据似乎争议。本报告提供了证据，证明体内和体外数据之间的差异，并提供了抑制性神经递质在没有障碍的情况下达到平滑的肌肉细胞，而ICC不存在。基金肌肉组织显示对物质p介导的内转的响应增加，并显示出明显的自发性活性，这与肌肉兴奋性增加一致。

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