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首页> 外文期刊>American Journal of Physiology >Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice
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Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice

机译：急性降低的运动活性是西方饮食诱导的小鼠肥胖的主要原因

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First published November 20, 2007; doi:10.1152/ajpendo.00401.2007.-The aim of the present study was to investigate the short- and long-term effects of a high-fat Western diet (WD) on intake, storage, expenditure, and fecal loss of energy as well as effects on locomotor activity and thermogenesis. WD for only 24 h resulted in a marked physiological shift in energy homeostasis, including increased body weight gain, body fat, and energy expenditure (EE) but an acutely lowered locomotor activity. The acute reduction in locomotor activity was observed after only 3-5 h on WD. The energy intake and energy absorption were increased during the first 24 h, lower after 72 h, and normalized between 7 and 14 days on WD compared with mice given chow diet. Core body temperature and EE was increased between 48 and 72 h but normalized after 21 days on WD. These changes paralleled plasma T3 levels and uncoupling protein~(-1) expression in brown adipose tissue. After 21 days of WD, energy intake and absorption, EE, and body temperature were normalized. In contrast, the locomotor activity was reduced and body weight gain was increased over the entire 21-day study period on WD. Calculations based on the correlation between locomotor activity and EE in 2-h intervals at days 21-23 indicated that a large portion of the higher body weight gain in the WD group could be attributed to the reduced locomotor activity. In summary, an acute and persisting decrease in locomotor activity is most important for the effect of WD on body weight gain and obesity in mice.
机译：2007年11月20日第一次出版; DOI：10.1152 / ajpendo.00401.2007 .-本研究的目的是探讨高脂肪西部饮食（WD）对摄入，储存，支出和粪便损失的短期和长期影响作为运动活性和热生成的影响。只有24小时的WD导致能量稳态有明显的生理转变，包括增加体重增加，体脂和能量消耗（EE），而是一种急剧降低的运动活动。在WD仅3-5小时后观察到运动活性的急性降低。在前24小时期间，在72小时后较低的能量摄入和能量吸收，与给予味道饮食的小鼠相比，在Wd的7至14天之间标准化。核心温度和EE在48到72小时之间增加，但在WD上21天后标准化。这些改变了棕色脂肪组织中的并联等离子体T3水平和解偶联蛋白〜（-1）表达。 WD的21天后，归一化能量摄入和吸收，EE和体温。相比之下，在WD的整个21天的研究期间，运动活性降低，体重增加增加。基于运动活性和EE之间的相关性在第21-23天间隔之间的相关性表明，WD组中的大部分体重增加的大部分较高可能归因于减少的运动活性。总之，运动活性的急性和持续性降低对于WD对小鼠体重增加和肥胖的影响最重要。

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