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首页> 外文期刊>American Journal of Physiology >Insulin sensitivity and metabolic flexibility following exercise training among different obese insulin-resistant pheno-types.
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Insulin sensitivity and metabolic flexibility following exercise training among different obese insulin-resistant pheno-types.

机译：在不同肥胖胰岛素抗性酚类类型中运动训练后胰岛素敏感性和代谢灵活性。

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Impaired fasting glucose (IFG) blunts the reversal of impaired glucose tolerance (IGT) after exercise training. Metabolic inflexibility has been implicated in the etiology of insulin resistance; however, the efficacy of exercise on peripheral and hepatic insulin sensitivity or substrate utilization in adults with IFG, IGT, or IFG + IGT is unknown. Twenty-four older (66.7 ± 0.8 yr) obese (34.2 ± 0.9 kg/m2) adults were categorized as IFG (n = 8), IGT (n = 8), or IFG + IGT (n = 8) according to a 75-g oral glucose tolerance test (OGTT). Subjects underwent 12-wk of exercise (60 min/day for 5 days/wk at -85% HRmax) and were instructed to maintain a eucaloric diet. A euglycemic hyperinsulinemic clamp (40 mUm2-min~1) with [6,6-2H]glucose was used to determine peripheral and hepatic insulin sensitivity. Nonoxidative glucose disposal and metabolic flexibility [insulin-stimulated respiratory quotient (RQ) minus fasting RQ] were also assessed. Glucose incremental area under the curve (iAUC_(OGTT)) was calculated from the OGTT. Exercise increased clamp-derived peripheral and hepatic insulin sensitivity more in adults with IFG or IGT alone than with IFG + IGT (P < 0.05). Exercise reduced glucose in IGT only (P < 0.05), and the decrease in glucose was inversely correlated with the increase in peripheral but not hepatic insulin sensitivity (P < 0.01). Increased clamp-derived peripheral insulin sensitivity was also correlated with enhanced metabolic flexibility, reduced fasting RQ, and higher nonoxidative glucose disposal (P < 0.05). Adults with IFG + IGT had smaller gains in clamp-derived peripheral insulin sensitivity and metabolic flexibility, which was related to blunted improvements in postprandial glucose. Additional work is required to assess the molecular mechanism(s) by which chronic hyperglycemia modifies insulin sensitivity following exercise training.
机译：空腹葡萄糖（IFG）患者患有运动训练后的葡萄糖耐量（IGT）的逆转。代谢抑旋性涉及胰岛素抵抗的病因;然而，锻炼对外周和肝胰岛素敏感性或底物利用的疗效，IFG，IGT或IFG + IgT未知。 24岁（66.7±0.8yr）肥胖（34.2±0.9 kg / m 2）成人分类为根据75的IFG（n = 8），IGT（n = 8），或IFG + IGT（n = 8） -G口服葡萄糖耐量试验（OGTT）。受试者经历了12-WK运动（60分钟/天5天/周，HRMAX），并被指示维持巩固饮食。使用[6,6-2H]葡萄糖的神经血糖高胰岛素纤维素夹（40 mum2-min〜1）用于确定外周和肝胰岛素敏感性。还评估了非氧化葡萄糖处理和代谢柔韧性[胰岛素刺激的呼吸呼吸型商（RQ）减去禁食RQ]。曲线下的葡萄糖增量区域（IAC_（OGTT））由OGTT计算。在单独的IFG + IGT中，锻炼更多地锻炼夹住衍生的外周和肝胰岛素敏感性更多，IFG或IGT（P <0.05）。在IGT中锻炼降低葡萄糖（P <0.05），并且葡萄糖的降低与外周血而不是肝胰岛素敏感性的增加相反（P <0.01）。增加的钳位衍生的外周胰岛素敏感性也与增强的代谢柔韧性，减少的禁食RQ和更高的非氧化葡萄糖处理相关（P <0.05）。具有IFG + IGT的成年人在钳位衍生的外周胰岛素敏感性和代谢柔性中具有较小的增益，这与餐后葡萄糖的改善有关。需要额外的工作来评估慢性高血糖在运动训练后改变胰岛素敏感性的分子机制。

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