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首页> 外文期刊>American Journal of Physiology >Antialbuminuric actions of calcilytics in the remnant kidney
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Antialbuminuric actions of calcilytics in the remnant kidney

机译：残留肾脏钙化糖尿病抗癫痫作用

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摘要

Hyperphosphatemia accelerates the progression of chronic kidney diseases. In the present study, the effects of ronacaleret, a calcilytic agent, on renal injury were assessed in the following four groups of rats: 5/6-nephrectomized Wistar rats as a control (C group), rats treated with ronacaleret (3 mg·kg~(-1)·day~(-1); R group), rats treated with calcitriol (30 ng·kg~(-1)·day~(-1); V group), and rats treated with both ronacaleret and calcitriol (R + V group). Three months later, rats were euthanized under anesthesia, and the remnant kidneys were harvested for analysis. Albuminuria was lower in the R and V groups than in the C group (P < 0.05). Creatinine clearance was elevated in the R and V groups compared with the C group (P < 0.05). Serum Ca~(2+) and renal ANG II were higher in the R + V group than in the C group (P < 0.05 for each), and serum phosphate was reduced in the R group compared with the C group (P < 0.05). Fibroblast growth factor-23 was lower in the R group and higher in the V and R + V groups than in the C group. However, parathyroid hormone did not differ significantly among the four groups. Renal klotho expression was elevated in the R and V groups compared with the C group (P < 0.05). The present data indicate that ronacaleret preserves klotho expression and renal function with reductions in serum phosphate and albuminuria in 5/6-nephrectomized rats. Our findings demonstrate that vitamin D prevents declines in klotho expression and renal function, suppressing albuminuria.
机译：高渗血症加速慢性肾病的进展。在本研究中，在以下四组大鼠中评估ronacaleret，钙酸盐剂，钙损伤对肾损伤的影响：5/6 - 肾上腺化Wistar大鼠作为对照（C组），用ronacaleret治疗的大鼠（3 mg· kg〜（-1）·日〜（-1）; r群），用辛酸处理的大鼠（30 ng·kg〜（-1）·日〜（-1）; v组），以及用ronacaleret治疗的大鼠和钙质（R + V族）。三个月后，大鼠在麻醉下被安乐死，收获残余的肾脏进行分析。 r和v组中的白蛋白尿低于c组（p <0.05）。与C组相比，r和v组肌酐清除率升高（P <0.05）。 R + V组血清Ca〜（2+）和肾II高于C组（每次P <0.05），与C组相比，R组中血清磷酸盐（P <0.05 ）。成纤维细胞生长因子-33在R组中较低，V和R + V组高于C组。然而，四组中的甲状旁腺激素并没有显着差异。与C组比较（P <0.05），R和V组中肾klotho表达升高。目前的数据表明，Ronacaleret在5/6 - 肾切除大鼠中抑制了血清磷酸盐和白蛋白尿中的葡萄干表达和肾功能。我们的研究结果表明，维生素D可防止克罗托表达和肾功能下降，抑制白蛋白尿。

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