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首页> 外文期刊>American Journal of Physiology >Platinum-based chemotherapy: gastrointestinal immunomodulation and enteric nervous system toxicity
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Platinum-based chemotherapy: gastrointestinal immunomodulation and enteric nervous system toxicity

机译：基于铂疗效：胃肠免疫调节和肠道神经系统毒性

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The efficacy of chemotherapeutic treatment of colorectal cancer is challenged by severe gastrointestinal side effects, which include nausea, vomiting, constipation, and diarrhea. These symptoms can persist long after the treatment has been ceased. An emerging concept is the ability of platinum-based drugs to stimulate immunity, which is in contrast to conventional chemotherapeutic agents that are immunosuppressive. Here, we review the immu-nomodulatory aspects of platinum-based anticancer chemotherapeutics and their impact on gastrointestinal innervation. Given the bidirectional communication between the enteric nervous system and gastrointestinal immune system; exploring the consequences of platinum-induced immunogenicity will facilitate better understanding of gut dysfunction caused by chemotherapeutic agents. We propose that the development of future successful chemotherapeutics should rely on targeting the mechanisms underlying long-term gastrointestinal side effects.
机译：通过严重的胃肠道副作用挑战了结直肠癌的化学治疗治疗的疗效，包括恶心，呕吐，便秘和腹泻。 这些症状可以在停止处理后持续存在。 新兴的概念是铂类药物刺激免疫的能力，与常规的化学治疗剂相反，其与免疫抑制性的常规化学治疗剂相反。 在这里，我们审查了基于铂的抗癌化学治疗剂的IMMU-编者方面及其对胃肠道后视野的影响。 鉴于肠内神经系统与胃肠免疫系统之间的双向通信; 探索铂诱导的免疫原性的后果将有助于更好地了解由化学治疗剂引起的肠道功能障碍。 我们建议未来的成功化学治疗方法的发展应该依赖于靶向长期胃肠道副作用的机制。

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