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首页> 外文期刊>American Journal of Physiology >Effects of meal ingestion on intramyocellular ceramide concentrations and fractional de novo synthesis in humans
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Effects of meal ingestion on intramyocellular ceramide concentrations and fractional de novo synthesis in humans

机译：膳食摄取对人类脑内神经酰胺浓度和分数德诺人群的影响

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摘要

We investigated the effects of meal ingestion on intramyofibrillar (IMF) and subsarcolemmal (SS) ceramide metabolism in volunteers ranging from lean to obese. Thirty-eight women and men underwent a steady-state meal ingestion protocol that included a 6.5-h infusion of [U-~(13)C]palmitate and muscle biopsies 1.5 and 6.5 h after starting the tracer infusion. We measured IMF and SS sphingolipid concentrations and the contribution of plasma palmitate to intramyocellular C16:0 ceramide by use of LC-MS-MS. In response to meal ingestion SS C24 ceramide concentrations, but not C14-C20 concentrations, increased significantly. IMF ceramide concentrations did not change. The increases in SS C24 ceramides were negatively related to parameters of insulin resistance. The fractional contribution of plasma palmitate to intramyocellular C16:0 ceramides in both IMF and SS fractions was inversely related to overweight status (β = -0.432, P = 0.0095 and β = -0.443, P = 0.0058, respectively). These data indicate that meal ingestion has differing effects on SS ceramide subspecies and suggest that the fractional de novo synthesis of intramyocellular ceramide from plasma palmitate in the postprandial condition is reduced in those who are overweight.
机译：我们调查了膳食摄入对患有瘦肉中的脑内纤维酒（IMF）和子系统胺（SS）神经酰胺代谢的影响。三十八名女性接受了稳态的膳食摄入方案，其中包括6.5-H输注[U-〜（13）c]棕榈酸盐和肌肉活组织检查1.5和6.5h，在开始示踪剂输注后。通过使用LC-MS-MS测量IMF和SS鞘脂浓度和血浆棕榈酸酯对脑内C16：0神经酰胺的贡献。响应于膳食摄入SS C24神经酰胺浓度，但不是C14-C20浓度，显着增加。 IMF神经酰胺浓度没有变化。 SS C24神经酰胺的增加与胰岛素抵抗的参数负相关。血浆棕榈酸酯在IMF和SS级分中对脑内粒细胞C16：0的分数贡献与超重状态（β= -0.432，P = 0.0095和β= -0.443，P = 0.0058分别）与超重状态相反。这些数据表明，膳食摄取对SS神经酰胺亚种具有不同的影响，并表明，在超重的那些中，从血浆棕榈酸盐中从血浆棕榈酸盐的分数De Novo合成减少。

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