首页> 外文期刊>American Journal of Physiology >Low-protein diet-induced hyperphagia and adiposity are modulated through interactions involving thermoregulation, motor activity, and protein quality in mice
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Low-protein diet-induced hyperphagia and adiposity are modulated through interactions involving thermoregulation, motor activity, and protein quality in mice

机译:通过涉及小鼠的热调节,运动活性和蛋白质质量的相互作用来调节低蛋白质饮食诱导的褐色和肥料

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摘要

Low protein (LP)-containing diets can induce overeating in rodents and possibly in humans in an effort to meet protein requirement, but the effects on energy expenditure (EE) are unclear. The present study evaluated the changes induced by reducing dietary protein from 20% to 6%—using either soy protein or casein—on energy intake, body composition, and EE in mice housed at 22°C or at 30°C (thermal neutrality). LP feeding increased energy intake and adiposity, more in soy-fed than in casein-fed mice, but also increased EE, thus limiting fat accumulation. The increase in EE was due mainly to an increase in spontaneous motor activity related to EE and not to thermoregulation. However, the high cost of thermoregulation at 22°C and the subsequent heat exchanges between nonshivering thermogenesis, motor activity, and feeding induced large differences in adaptation between mice housed at 22°C and at 30°C.
机译:低蛋白质(LP) - 含有饮食可以在啮齿动物中诱发暴饮暴食,并且可能在人类中努力满足蛋白质要求,但对能源消耗(EE)的影响尚不清楚。 本研究评估了将膳食蛋白从20%降至6%的膳食蛋白质诱导的变化 - 在22℃或30℃(热中立)的小鼠中,在小鼠中,对小鼠进行大豆蛋白或酪蛋白的能量摄取,身体组合物和EE 。 LP喂养能量摄入量增加和肥胖,更多的大豆喂养比在酪蛋白喂养小鼠中,也增加了EE,从而限制了脂肪积累。 EE的增加主要是由于与EE相关的自发电机活性增加,而不是温度调节。 然而,在22℃下的热调节成本高,随后的热交换器在不存在的热生成,电动机活性和饲养之间诱导在22℃和30℃的小鼠之间适应的巨大差异。

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