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首页> 外文期刊>Analytica chimica acta >Highly sensitive and selective electrochemical paper-based device using a graphite screen-printed electrode modified with molecularly imprinted polymers coated Fe3O4@Au@SiO2 for serotonin determination
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Highly sensitive and selective electrochemical paper-based device using a graphite screen-printed electrode modified with molecularly imprinted polymers coated Fe3O4@Au@SiO2 for serotonin determination

机译：使用石墨丝网印刷电极的高敏感和选择性的电化学纸纸装置，其用分子印迹聚合物涂覆Fe3O4 @ Au @ SiO 2进行血清素测定

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Herein, we propose a highly sensitive and selective three-dimensional electrochemical paper-based analytical device (3D-ePAD) to determine serotonin (Ser). It uses a graphite-paste electrode modified with nanoparticles coated with molecularly imprinted polymer (MIP). Fe3O4@Au nanoparticles were encapsulated with silica to create novel nano-sized MIP. Morphology and structural characterization reveal that silica imprinted sites (Fe3O4@Au@SiO2) synthesized via sol-gel methods provide excellent features for Ser detection, including high porosity, and greatly improve analyte diffusion and adsorption to provide a faster response by the MIP sensor. The template molecule was effectively removed by solvent extraction to provide a greater number of specific cavities that enhance analyte capacity and sensitivity. The 3D-ePAD was fabricated by alkyl ketene dimer (AKD)-inkjet printing of a circular hydrophobic detection zone on filter paper for application of aqueous samples, coupled with screen-printed electrodes on the paper, which was folded underneath the hydrophobic zone. The sensor was constructed by drop coating of Fe3O4@Au@SiO2-MIP nanocomposites on the graphite electrode (GPE) surface. The MIP sensor (Fe3O4@Au@SiO2-MIP/GPE) was used in the detection of Ser by linear-sweep voltammetry (LSV) in 0.1 M phosphate buffer at pH 8.0. The device exhibits high sensitivity toward Ser, which we attribute to synergistic effects between catalytic properties, electrical conductivity of Fe3O4@Au@SiO2, and significantly increased numbers of imprinted sites. Ser oxidation was observed at +0.39 V. Anodic peak currents for Ser show linearity from 0.01 to 1000 mu M (y = 0.0075 +/- 0.0049 x + 0.4071 +/- 0.0052, r(2) = 0.993), with a detection limit of 0.002 mu M (3S/N). The device provides good repeatability (% relative standard deviations; RSD) = 4.23%, calculated from the current responses of ten different MIP sensors). The device also exhibits high selectivity and reproducibility (% RSD = 8.35%, obtained from five calibration plots). The analytical performance of the device is suitable for the determination of Ser in pharmaceutical capsules and urine samples. (C) 2019 Elsevier B.V. All rights reserved.
机译：在此，我们提出了一种高敏感和选择性的三维电化学纸型分析装置（3D-EPAD）以确定血清素（SER）。它使用用分子印迹聚合物（MIP）涂覆的纳米颗粒改性的石墨糊电极。 Fe3O4 @ Au纳米颗粒用二氧化硅包封以产生新颖的纳米尺寸的MIP。形态学和结构表征揭示了通过溶胶 - 凝胶方法合成的二氧化硅印迹位点（Fe3O4 @ SiO 2）提供了SER检测的优异特征，包括高孔隙率，大大改善分析物扩散和吸附，以提供MIP传感器的更快响应。通过溶剂萃取有效地除去模板分子，以提供更多数量的特定腔，其增强分析物能力和敏感性。通过烷基酮二聚体（AKD） - 在滤纸上用圆形疏水检测区的烷基氯乙烯二聚体（AKD） - 孔喷涂制造3D-EPAD，用于涂覆水性样品，与纸张上的筛网印刷电极耦合，在疏水区下方折叠。通过在石墨电极（GPE）表面上的Fe3O4 @ Au @ SiO 2-MIP纳米复合材料的Fe 3 O 4-Au / a-MIP纳米复合物构成传感器。 MIP传感器（Fe3O4 @ Au @ SiO 2-MIP / GPE）用于在pH8.0的0.1M磷酸盐缓冲液中通过线性扫描伏安法（LSV）检测Ser。该装置对Ser表现出高敏感性，我们将催化性质，Fe3O4 @ Au @ SiO 2的电导率之间的协同效应归因于催化性质，并且显着增加了印迹位点的数量。在+ 0.39 V.阳极氧化峰电流的情况下，SER显示线性度为0.01至1000μm（Y = 0.0075 +/- 0.0049×+ 0.4071 +/- 0.0052，R（2）= 0.993），具有检测限0.002 mu m（3s / n）。该器件提供良好的重复性（％相对标准偏差; RSD）= 4.23％，从10个不同的MIP传感器的当前响应计算）。该器件还具有从五个校准图获得的高选择性和再现性（％RSD = 8.35％）。该装置的分析性能适用于在药物胶囊和尿液样品中的确定。 （c）2019年Elsevier B.V.保留所有权利。

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