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首页> 外文期刊>Applied Microbiology and Biotechnology >Atrorosins: a new subgroup of Monascus pigments from Talaromyces atroroseus
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Atrorosins: a new subgroup of Monascus pigments from Talaromyces atroroseus

机译：阿托罗斯汀：来自Talaromyces Atroroseus的新蒙马斯色素亚组

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摘要

A new series of azaphilone pigments named atrorosins have been isolated from the filamentous fungus Talaromyces atroroseus. Atrorosins have a similar azaphilone scaffold as the orange Monascus pigment PP-O, with a carboxylic acid group at C-1, but are unique by their incorporation of amino acids into the isochromene system. Despite that the atrorosin precursor PP-O, during fermentation, was initially produced as two isomers (3:2, cis:trans ratio), the atrorosins were surprisingly almost exclusively (99.5%) produced as the cis-form, possibly due to steric interactions with the incorporated amino acid. When grown on complex media, a whole range of atrorosins is produced, whereas individual atrorosins can be produced selectively during fermentation by supplementing with the desired primary amine-containing compound.
机译：一系列名为Atrorosins的新系列的共止向素颜料已从丝状真菌塔罗芥atroroseus中分离出来。 阿托膦蛋白具有与橙色普通话颜料PP-O相似的Azaphilone支架，其在C-1处具有羧酸基团，但通过将氨基酸掺入异罗丙烯系统中是独特的。 尽管在发酵期间的阿托罗铝前体PP-O最初由两种异构体（3：2，CIS：反式比）产生，但阿灭菌素几乎完全（99.5％）作为顺式形式产生的（99.5％），可能是由于空间 与掺入的氨基酸相互作用。 当在复杂培养基上生长时，产生整个阿哈托膦，而通过补充所需的初级胺化合物，可以在发酵过程中选择性地制备各种紫藤素。

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