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CRISPR/Cas9-based genome editing of the filamentous fungi: the state of the art

机译：基于CRISPR / CAS9的基因组编辑丝状真菌：现有技术

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摘要

In recent years, a variety of genetic tools have been developed and applied to various filamentous fungi, which are widely applied in agriculture and the food industry. However, the low efficiency of gene targeting has for many years hampered studies on functional genomics in this important group of microorganisms. The emergence of CRISPR/Cas9 genome-editing technology has sparked a revolution in genetic research due to its high efficiency, versatility, and easy operation and opened the door for the discovery and exploitation of many new natural products. Although the application of the CRISPR/Cas9 system in filamentous fungi is still in its infancy compared to its common use in E. coli, yeasts, and mammals, the deep development of this system will certainly drive the exploitation of fungal diversity. In this review, we summarize the research progress on CRISPR/Cas9 systems in filamentous fungi and finally highlight further prospects in this area.
机译：近年来，已经开发出各种遗传工具和应用于各种丝状真菌，这些丝状真菌广泛应用于农业和食品工业。 然而，基因靶向的低效率是多年的多年对该重要微生物群体的功能基因组学的研究。 由于其高效率，多功能性和操作，开辟了遗传研究的出现，激励/ Cas9基因组编辑技术引发了遗传研究的革命。 虽然在丝状真菌中的CRAP / CAS9系统的应用仍然是其婴儿的缺乏，但与其在大肠杆菌，酵母和哺乳动物中的常见使用相比，该系统的深度发展肯定会推动真菌多样性的利用。 在这篇综述中，我们总结了丝状真菌中CRISPR / CAS9系统的研究进展，最后强调了该地区的进一步前景。

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  • 来源
  • 作者

    Shi Tian-Qiong; Liu Guan-Nan; Ji Rong-Yu; Shi Kun; Song Ping; Ren Lu-Jing; Huang He; Ji Xiao-Jun;

  • 作者单位

    Nanjing Tech Univ Coll Biotechnol &

    Pharmaceut Engn 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Coll Biotechnol &

    Pharmaceut Engn 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Coll Biotechnol &

    Pharmaceut Engn 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Coll Biotechnol &

    Pharmaceut Engn 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Coll Biotechnol &

    Pharmaceut Engn 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Coll Biotechnol &

    Pharmaceut Engn 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Sch Pharmaceut Sci 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Coll Biotechnol &

    Pharmaceut Engn 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 应用微生物学;生物工程学（生物技术）;
  • 关键词

    CRISPR/Cas9; Application; Filamentous fungi; Genome editing;

    机译：CRISPR / CAS9;应用;丝状真菌;基因组编辑;

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