Associations Between Driver Gene Mutations and Cytotoxic Chemosensitivity in Patients with Non-small Cell Lung Cancer

Morodomi Yosuke; Okamoto Tatsuro; Kohno Mikihiro; Katsura Masakazu; Takada Kazuki; Suzuki Yuzo; Fujishita Takatoshi; Kitahara Hirokazu; Shimamatsu Shinichiro; Yoshida Tsukihisa; Tagawa Tetsuzo; Okano Shinji; Maehara Yoshihiko

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Associations Between Driver Gene Mutations and Cytotoxic Chemosensitivity in Patients with Non-small Cell Lung Cancer

机译：非小细胞肺癌患者司机基因突变与细胞毒性化学敏感性的关联

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Background/Aim: Patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) gene mutations or echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-ALK) rearrangement often have a better prognosis when they are treated with specific inhibitors than when treated with cytotoxic agents. However, the associations between gene mutations and cytotoxic chemosensitivity are still unclear. The objective of the present study was to identify which clinicopathological factors, including genetic mutations, influence chemosensitivity, determined using the succinate dehydrogenase inhibition (SDI) test in patients with NSCLC. Materials and Methods: The chemosensitivity of tumor tissues from 96 patients with NSCLC who underwent surgical resection was evaluated using the SDI test. Results: In patients with adenocarcinoma, tumors with EGFR gene mutations were significantly more sensitive to 5-fluorouracil (5-FU) than tumors without EGFR gene mutations (p<0.0149). Conclusion: Our data suggest that patients with adenocarcinoma harboring EGFR gene mutations may be susceptible to 5-FU.

机译：背景/目的：非小细胞肺癌（NSCLC）患有表皮生长因子受体（EGFR）基因突变或海螺肽微管相关蛋白质样4Anpplastic淋巴瘤激酶（EML4-ALK）重排通常具有更好的预后用特异性抑制剂治疗，而不是用细胞毒性剂处理。然而，基因突变和细胞毒性化学敏感性之间的关联仍然不清楚。本研究的目的是鉴定哪些临床病理因素，包括遗传突变，影响使用NSCLC患者的琥珀酸脱氢酶抑制（SDI）试验确定的临床突变。材料和方法：使用SDI试验评估了96例接受手术切除的NSCLC患者的肿瘤组织的化学敏感性。结果：在腺癌患者中，患有EGFR基因突变的肿瘤对5-氟尿嘧啶（5-FU）的肿瘤显着比没有EGFR基因突变的肿瘤（P <0.0149）。结论：我们的数据表明，患有EGFR基因突变的腺癌患者可能易于5-FU。

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来源
《Anticancer Research: International Journal of Cancer Research and Treatment》 |2015年第3期|共6页
作者
Morodomi Yosuke; Okamoto Tatsuro; Kohno Mikihiro; Katsura Masakazu; Takada Kazuki; Suzuki Yuzo; Fujishita Takatoshi; Kitahara Hirokazu; Shimamatsu Shinichiro; Yoshida Tsukihisa; Tagawa Tetsuzo; Okano Shinji; Maehara Yoshihiko;
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作者单位

Kyushu Univ Grad Sch Med Sci Dept Surg &

Sci Fukuoka 8128582 Japan;

Kyushu Univ Grad Sch Med Sci Dept Surg &

Sci Fukuoka 8128582 Japan;

Kyushu Univ Grad Sch Med Sci Dept Surg &

Sci Fukuoka 8128582 Japan;

Kyushu Univ Grad Sch Med Sci Dept Surg &

Sci Fukuoka 8128582 Japan;

Kyushu Univ Grad Sch Med Sci Dept Surg &

Sci Fukuoka 8128582 Japan;

Kyushu Univ Grad Sch Med Sci Dept Surg &

Sci Fukuoka 8128582 Japan;

Kyushu Univ Grad Sch Med Sci Dept Surg &

Sci Fukuoka 8128582 Japan;

Kyushu Univ Grad Sch Med Sci Dept Surg &

Sci Fukuoka 8128582 Japan;

Kyushu Univ Grad Sch Med Sci Dept Surg &

Sci Fukuoka 8128582 Japan;

Kyushu Univ Grad Sch Med Sci Dept Surg &

Sci Fukuoka 8128582 Japan;

Kyushu Univ Grad Sch Med Sci Dept Surg &

Sci Fukuoka 8128582 Japan;

Kyushu Univ Dept Innovat Appl Oncol Fukuoka 8128582 Japan;

Kyushu Univ Grad Sch Med Sci Dept Surg &

Sci Fukuoka 8128582 Japan;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Non-small cell lung cancer; anaplastic lymphoma kinase; epidermal growth factor receptor; chemosensitivity;

机译：非小细胞肺癌;一个气相生线淋巴瘤激酶;表皮生长因子受体;化学敏感性;

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专利

1. Associations Between Driver Gene Mutations and Cytotoxic Chemosensitivity in Patients with Non-small Cell Lung Cancer [J] . Morodomi Yosuke, Okamoto Tatsuro, Kohno Mikihiro, Anticancer Research: International Journal of Cancer Research and Treatment . 2015,第3期

机译：非小细胞肺癌患者司机基因突变与细胞毒性化学敏感性的关联
2. Low frequency KRAS mutations in colorectal cancer patients and the presence of multiple mutations in oncogenic drivers in non-small cell lung cancer patients [J] . JiangL., HuangJ., MorehouseC., Cancer genetics . 2013,第9a10期

机译：非小细胞肺癌患者大肠癌患者的低频KRAS突变和致癌驱动因素中的多个突变
3. Overall survival of driver mutation-negative non-small cell lung cancer patients with COPD under chemotherapy compared to non-COPD non-small cell lung cancer patients [J] . Jeong Uk Lim, Chang Dong Yeo, Chin Kook Rhee, International Journal of Chronic Obstructive Pulmonary Disease . 2018,第1期

机译：与非COPD非小细胞肺癌患者相比，驱动突变突变阴性的COPD非小细胞肺癌患者接受化疗的总体生存期
4. Association between tumor heterogeneity and progression-free survival in non-small cell lung cancer patients with EGFR mutations undergoing tyrosine kinase inhibitors therapy [C] . Jiangdian Song, Di Dong, Yanqi Huang, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2016

机译：接受酪氨酸激酶抑制剂治疗的EGFR突变非小细胞肺癌患者肿瘤异质性与无进展生存的关系
5. Pharmacology Profiles of ALK and FLT3 Kinase Inhibitors against Non-Small-Cell Lung Cancer Cells and Acute Myeloid Leukemia Cells with Cancer Driver Mutations [D] . 森政道 2019

机译：ALK和FLT3激酶抑制剂对非小细胞肺癌细胞和急性髓系白血病细胞的癌症驱动突变的药理作用
6. Genomic Profiling of Driver Gene Mutations in Chinese Patients With Non-Small Cell Lung Cancer [O] . Hongxue Meng, Xuejie Guo, Dawei Sun, 2019

机译：中国非小细胞肺癌患者司机基因突变基因组分析
7. Genomic Profiling of Driver Gene Mutations in Chinese Patients With Non-Small Cell Lung Cancer [O] . Hongxue Meng, Xuejie Guo, Dawei Sun, 2019

机译：中国非小细胞肺癌患者司机基因突变基因组分析

Associations Between Driver Gene Mutations and Cytotoxic Chemosensitivity in Patients with Non-small Cell Lung Cancer

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