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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Effect of Anaesthetic Technique on Immune Cell Infiltration in Breast Cancer: A Follow-up Pilot Analysis of a Prospective, Randomised, Investigator-masked Study
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Effect of Anaesthetic Technique on Immune Cell Infiltration in Breast Cancer: A Follow-up Pilot Analysis of a Prospective, Randomised, Investigator-masked Study

机译：麻醉药对乳腺癌免疫细胞浸润的影响：一种前瞻性，随机，调查员研究的后续试验分析

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Background: Live animal studies using an inoculation model of breast cancer indicate that anaesthetic drugs and techniques differentially affect cancer metastasis, inversely related to Natural Killer (NK) cell and T lymphocyte levels. Clinical histological studies demonstrate that the distribution of these immune cells and macrophages in intra-tumoral cancer tissue can predict prognosis and response to therapy. No study has evaluated whether the anaesthetic technique influences human breast cancer immune cell infiltration. Materials and Methods: Excised breast cancer specimens from patients previously enrolled in an ongoing, prospective, randomised trial (NCT00418457) investigating the effect of anaesthetic technique on long-term breast cancer outcome were immunohistochemically stained to enable a colour deconvolution technique to summate marked immune cell infiltration: CD56 (NK CD4 (T helper cells), CD8 (T suppressor cells) and CD68 (macrophages). Patients were randomised to receive either a propofol-paravertebral anaesthetic with continuing analgesia (PPA, n=12) or a balanced general anaesthesia with opioid analgesia (GA, n=16) for 24 h postoperatively. Investigators were masked to group allocation. Results: Normalised positive intensity values, (median (interquartile range (IQR)), for CD56 were lower in GA121 (116-134) versus 136 (132-142), p=0.015. CD4 was also lower in GA10.9 (5.5-27.8) versus PPA 19.7(14.4-83.5), p=0.03 but CD8 5.5 (4.0-9.75) versus 13.0 (5.0-14.5) respectively, p=0.24 and CD 68 infiltration 5.8 (3.25-8.75) versus 8.0 (3.0-8.75), p=0.74 were not significantly different. Conclusion: PPA induces increased levels of NK and T helper cell infiltration into breast cancer tissue compared with GA but not T suppressor cells or macrophages. This is consistent with the hypothesis that the anaesthetic technique may affect perioperative immune function conducive to resisting breast cancer recurrence and metastasis.
机译：背景：使用乳腺癌的接种模型的活动物研究表明麻醉药物和技术差异地影响癌症转移，与天然杀伤（NK）细胞和T淋巴细胞水平反比。临床组织学研究表明，肿瘤内癌组织中这些免疫细胞和巨噬细胞的分布可以预测预后和对治疗的反应。没有研究评估麻醉技术是否影响人乳腺癌免疫细胞浸润。材料和方法：以前从持续的患者中注册的乳腺癌标本调查麻醉技术对长期乳腺癌结果的影响，以免疫组织化学染色，以使颜色去卷积技术能够结束标记的免疫细胞浸润：CD56（NK CD4（T辅助细胞），CD8（T抑制细胞）和CD68（巨噬细胞）。随机随机接受持续镇痛（PPA，N = 12）或平衡的全身麻醉患者术后24小时的阿片类镇痛（Ga，n = 16）。掩盖了调查人员组分配。结果：GA121的CD56的归一化正强度值（中位数（IQR））（116-134）较低与136（132-142），p = 0.015。CD4在GA10.9（5.5-27.8）相对于PPA 19.7（14.4-83.5），P = 0.03但CD8 5.5（4.0-9.75）与13.0（5.0- 14.5）分别，p = 0.24和CD 68 I NFiltration 5.8（3.25-8.75）与8.0（3.0-8.75），P = 0.74没有显着差异。结论：与GA但不是T抑制细胞或巨噬细胞相比，PPA诱导乳腺癌组织增加了NK和T辅助细胞浸润水平。这与麻醉技术可能影响围手术化免疫功能有利于抵抗乳腺癌复发和转移的假设一致。

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