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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Amentoflavone Induces Anti-angiogenic and Anti-metastatic Effects Through Suppression of NF-kappa B Activation in MCF-7 cells
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Amentoflavone Induces Anti-angiogenic and Anti-metastatic Effects Through Suppression of NF-kappa B Activation in MCF-7 cells

机译：Amenoflavone通过抑制MCF-7细胞中的NF-Kappa B活化来诱导抗血管生成和抗转移效果

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摘要

The aim of the present study was to investigate whether amentoflavone induces anti-angiogenic and anti-metastatic effects through suppression of NF-kappa B activation in breast cancer in vitro. Effects of NF-kappa B inhibitor 4-N[2-(4-phenoxyphenyl)ethyl]quinazoline-4, 6-diamine (QNZ) and amentoflavone on the expression and secretion of angiogenesis-and metastasis-related proteins and cell invasion were investigated by western blotting, enzyme-linked immunosorbent assay (ELISA), and invasion assays. We also verified the effects of QNZ and amentoflavone on lipopolysaccharides (LPS)-activated cell invasion. Obtained results indicated that both QNZ and amentoflavone reduce NF-kappa B activation, expression and secretion of angiogenesis-and metastasis-related proteins, and cell invasion. QNZ and amentoflavone also reverse LPS-activated cell invasion. In conclusion, inhibition of NF-kappa B activation decreases expression and secretion of angiogenesis-and metastasis-related proteins. Amentoflavone may induce anti-angiogenic and antimetastatic effects through suppression of NF-kappa B activation.
机译：本研究的目的是探讨Ameroflavone是否通过抑制乳腺癌中的NF-Kappa B活化在体外诱导抗血管生成和抗转移效应。 NF-Kappa抑制剂4-N [2-（4-苯氧基苯基）乙基]喹唑啉-4,6-二胺（QNZ）和Amentoflavone对血管生成和转移相关蛋白和细胞侵袭的表达和分泌的影响通过蛋白质印迹，酶联免疫吸附测定（ELISA）和侵袭测定。我们还验证了QNZ和Ameroflavone对脂多糖（LPS）术语 - 活化细胞侵袭的影响。获得的结果表明，QNZ和Amenoflavone均降低NF-κB激活，表达和分泌血管生成和转移相关蛋白质和细胞侵袭。 QNZ和Amenoflavone还反转LPS激活的细胞侵入。总之，NF-Kappa B激活的抑制降低了血管生成和转移相关蛋白的表达和分泌。通过抑制NF-Kappa B激活，Amentoflavone可以诱导抗血管生成和抗体效应。

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