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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Evidence of F-18-FCH Uptake in Human T98G Glioblastoma Cells
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Evidence of F-18-FCH Uptake in Human T98G Glioblastoma Cells

机译：人T98G胶质母细胞瘤细胞F-18-FCH吸收的证据

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摘要

Aim: Tumor and chemo/radiotherapy-damaged brain tissues are hardly distinguishable by conventional morphological imaging. F-18-FCH was compared against F-18-FDG in the T98G glioblastoma cell line with regard to their radiopharmaceutical uptake, in order to test its diagnostic power on brain tumor lesions. Materials and Methods: Equimolar amounts of F-18-FCH and F-18-FDG were added to human glioblastoma T98G cells and human dermal fibroblasts for 20, 40, 60, 90 and 120 min of incubation. Radiopharmaceutical uptake was expressed as a percentage of the administered dose. Cold choline was used for binding competition experiments. Results: In T98G cells F-18-FCH was taken-up in higher amounts than F-18-FDG after 60 min. In fibroblasts, uptake was lower than 1% for both radiopharmaceuticals. Cold choline reduced the uptake of FCH to 1% similarly to fibroblasts. Conclusion: Our results prove the efficacy of F-18-FCH as a promising tracer, better than F-18-FDG in establishing the tumor-to-background ratio in brain tumors.
机译：目的：肿瘤和化疗/放射疗法受损的脑组织几乎不能通过常规形态学成像区分。将F-18-FCH与T98G胶质母细胞瘤细胞系的F-18-FCG进行比较，关于其放射性药物摄取，以测试其对脑肿瘤病变的诊断功能。材料和方法：将Equimolar量为F-18-FCH和F-18-FDG加入人胶质母细胞瘤T98G细胞和人的皮肤成纤维细胞20,40,60,90和120分钟。放射性药物摄取表达为施用剂量的百分比。冷胆碱用于结合竞争实验。结果：在60分钟后，在T98G细胞中占据F-18-FCH的含量高于F-18-FDG。在成纤维细胞中，两个放射性药物的摄取低于1％。冷胆碱与成纤维细胞类似地降低了FCH至1％的吸收。结论：我们的结果证明了F-18-FCH作为有前途的示踪剂的功效，优于F-18-FDG，在脑肿瘤中建立肿瘤到背景比率。

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