...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Clinical Significance of Expression of Nephroblastoma Overexpressed (NOV) in Patients with Colorectal Cancer
【24h】

Clinical Significance of Expression of Nephroblastoma Overexpressed (NOV) in Patients with Colorectal Cancer

机译：结直肠癌患者肾细胞瘤表达的临床意义

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: The nephroblastoma overexpressed (NOV) gene, which belongs to the cysteine-rich, angiogenic inducer 61/connective tissue growth factor/nephroblastoma overexpressed (CCN) family, is located in the 8q24 region and promotes migration and invasiveness in several types of malignancies. We explored the clinical significance of NOV expression in colorectal cancer (CRC). Materials and Methods: NOV expression in CRC specimens and CRC cell lines were evaluated. The association between the clinicopathlogical factors and NOV mRNA expression of tumor tissues was assessed in 126 patients with CRC. We assessed the relationships between NOV expression and overall survival in public databases. We performed overexpression experiments in vitro. Results: CRC specimens and CRC cell lines showed high NOV expression. High NOV mRNA expression was correlated with poorer overall survival and higher Union for International Cancer Control (UICC) T factor. In public databases, high NOV expression was associated with poorer prognoses. Overexpression of NOV promoted invasiveness of CRC cells. Conclusion: NOV may be an indicator of poor prognosis and a therapeutic target in CRC.
机译：背景：肾细胞瘤过表达（11月）基因属于富含半胱氨酸的血管生成的诱导症61 /结缔组织生长因子/肾脏母细胞瘤过表达（CCN）家族，位于8Q24区域，并促进了几种类型的恶性肿瘤中的迁移和侵袭性。我们探讨了11月在结肠直肠癌（CRC）中表达的临床意义。材料和方法：评估CRC标本和CRC细胞系中的11个表达。在126例CRC患者中评估临床病理因子和肿瘤组织的11月MRNA表达之间的关联。我们评估了11月在公共数据库中的表达和整体生存之间的关系。我们在体外进行过表达实验。结果：CRC标本和CRC细胞系显示高11个表达。高11个mRNA表达与国际癌症控制（UICC）T因子的整体存活率和更高的联盟相关。在公共数据库中，高11个表达式与较差的预期相关联。促进CRC细胞促进侵袭性的11月过度表达。结论：11月可能是预后差和CRC治疗靶标的指标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号