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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Sulfobetaine (Dimethylsulfoniopropionate) and Glycine Betaine Show Incompatible Involvement in Crucial Ehrlich Ascites Carcinoma in Mice
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Sulfobetaine (Dimethylsulfoniopropionate) and Glycine Betaine Show Incompatible Involvement in Crucial Ehrlich Ascites Carcinoma in Mice

机译：磺基因（二甲基磺基丙酸酯）和甘氨酸甜菜碱表现出对小鼠的关键ehrlich腹水癌的不相容

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Background/Aim: The role of methylation reactions in cancer was examined using the methylating agents, sulfobetaine [dimethylsulfonioproponate (DMSP)], and glycine betaine (GB), in murine crucial Ehrlich ascites carcinoma (EAC) for up to 10 days. Results: DMSP administration in EAC-bearing mice mitigated EAC, while GB administration clearly promoted EAC. However, the immune cell profiles did not differ largely between animals receiving DMSP and those receiving GB. Moreover; DMSP and GB had merely any effects on proliferation of EAC cells in vitro. Injection of DMSP into normal mice interestingly led to macrophage accumulation in the peritoneal cavity in a dose-dependent manner at early rearing. Conclusion: These results indicate that GB promoted EAC by the methylation of cancer promotor gene, whereas DMSP ameliorated EAC by the accumulation of activated macrophages with a rapid response and long life span during cancer progression.
机译：背景/目的：使用甲基化试剂，磺基丙酮[二甲基磺酰丙酸酯（DMSP）]和甘氨酸甜菜碱（GB），在鼠关键型癌症癌（EAC）中的甲基化试剂，长达10天，检查癌症中甲基化反应的作用。 结果：EAC-轴承小鼠的DMSP管理缓解EAC，而GB管理明确促进了EAC。 然而，免疫细胞谱在接受DMSP和接收GB的动物之间没有差异。 而且; DMSP和GB仅对体外对EAC细胞增殖的任何影响。 将DMSP注入有趣的正常小鼠，在早期饲养时以剂量依赖性方式导致腹膜腔中的巨噬细胞积累。 结论：这些结果表明，GB通过癌促进剂基因的甲基化促进了EAC，而DMSP改善了EAC，通过激活的巨噬细胞积累了癌症进展期间的快速反应和长寿命。

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