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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Lifetime UVR Dose and Skin Cancer Risk, Determined by Their Common Relation to Solar Lentigines
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Lifetime UVR Dose and Skin Cancer Risk, Determined by Their Common Relation to Solar Lentigines

机译：终身UVR剂量和皮肤癌症风险，由他们与太阳能赛的共同关系决定

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Background/Aim: Ultraviolet radiation (UVR) causes solar lentigines (SL) and skin cancer (SC) in humans. The association between measured lifetime UVR dose and SC has not been investigated. This study investigated this relation through their common relationship to SL. Materials and Methods: First we investigated the association between lifetime UVR dose and SL for 16,897 days in 38 healthy participants, and secondly, the relation between SL and SC was investigated in 2,898 participants, including 149 with SC. By combining both studies, SC risk related to lifetime UVR dose and skin phototype was estimated. Results: A positive association was found between SL and lifetime UVR dose (p=0.060). Skin phototype (p=0.001) and SL (p< 0.001) were associated with SC. Combined SC risk increased 1.23 by doubling the average lifetime UVR dose and was 34.9 times higher for those with very fair skin compared to dark Mediterranean skin. Conclusion: The estimate of SC risk shows that skin phototype is of greater relative importance than lifetime UVR dose.
机译：背景/目的：紫外线辐射（UVR）导致人类中的太阳赛素（SL）和皮肤癌（SC）。尚未研究测量的寿命UVR剂量和SC之间的关联。本研究通过与SL的共同关系调查了这一关系。材料和方法：首先，在38名健康参与者中调查了终身UVR剂量和SL之间的关联16,897天，其次，在2,898名参与者中研究了SL和SC之间的关系，其中包括SC。通过结合研究，估计与终身UVR剂量和皮肤光型相关的SC风险。结果：在SL和终身UVR剂量之间发现阳性关联（P = 0.060）。皮肤光学型（P = 0.001）和SL（P <0.001）与SC相关。综合SC风险将平均寿命UVR剂量加倍增加1.23，对于皮肤非常公平的皮肤，与黑暗的地中海皮肤相比，那些较高的34.9倍。结论：SC风险的估计表明，皮肤光型具有比寿命UVR剂量更大的重要性。

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