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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Tumor Response in Esophageal Squamous Cell Carcinoma Treated With Neoadjuvant Chemotherapy Followed by Surgery
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Tumor Response in Esophageal Squamous Cell Carcinoma Treated With Neoadjuvant Chemotherapy Followed by Surgery

机译：用新辅助化疗治疗食管鳞状细胞癌的肿瘤反应，然后进行手术治疗

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Background/Aim: Neoadjuvant therapy followed by surgery is the standard treatment for advanced esophageal cancer. This study aimed to evaluated the potential of F-18-fluorodeoxyglucose positron-emission tomography to predict the pathological therapeutic effect of neoadjuvant chemotherapy. Patients and Methods: We enrolled 68 patients with advanced esophageal squamous cell carcinoma who underwent F-18-fluorodeoxyglucose positron-emission tomography before and after neoadjuvant chemotherapy, followed by surgery. Retrospective analysis of the pathological therapeutic effects was performed. Results: The pathological therapeutic effect of good responders was significantly inversely associated with the maximum standardized uptake value (SUVmax) after neoadjuvant chemotherapy and with SUVmax reduction (both p<0.0001). Univariate and multivariate analyses revealed that lower post therapy SUVmax and reduction in SUVmax were independent prognostic factors for relapse-free (p=0.02) and overall survival (p<0.0001). Conclusion: Post-neoadjuvant chemotherapy SUVmax and SUVmax reduction can predict the pathological therapeutic effect of neoadjuvant chemotherapy.
机译：背景/目的：新辅助治疗随后进行手术是前进食管癌的标准治疗方法。本研究旨在评估F-18-氟脱氧葡萄糖正电子排放断层扫描的潜力，以预测Neoadjuvant化疗的病理治疗效果。患者和方法：我们注册了68例治疗前后氟脱氧葡萄糖正电子排放断层扫描的68例患有先进的食管鳞状细胞癌，在新辅助化疗之前和之后，然后进行手术。进行了对病理治疗效果的回顾性分析。结果：良性响应者的病理治疗效果与新辅助化疗后最大标准化摄取值（SUVMAX）与Suvmax降低（P <0.0001）的最大标准化摄取值（Suvmax）相关。单变量和多变量分析显示，降低的后治疗Suvmax和Suvmax的还原是无休止的复发（P = 0.02）和总存活的预后因素（P <0.0001）。结论：新辅助化疗Suvmax和Suvmax降低可预测Neoadjuvant化疗的病理治疗效果。

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