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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Circulating Tumor DNA in Saliva in an Orthotopic Head and Neck Cancer Mouse Model
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Circulating Tumor DNA in Saliva in an Orthotopic Head and Neck Cancer Mouse Model

机译：在原位头颈癌小鼠模型中唾液中循环肿瘤DNA

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Aim: To evaluate the feasibility of conducting studies of saliva circulating tumor DNA (ctDNA) as a biomarker of metastasis or recurrence in our orthotopic head and neck cancer (HNC) mouse model. Materials and Methods: A mouse model of recurrence or metastasis after tongue cancer resection was developed. Blood and saliva were collected at baseline and at the establishment of recurrence or metastasis. Real-time polymerase chain reaction was performed to quantify human long interspersed element (hLINE) in samples to assess the amount of ctDNA. Results: In our model, salivary hLINE increased as the cancer developed and decreased after surgery. Plasma hLINE was significantly elevated in mice with metastasis. The presence of tongue cancer recurrence in mice was more correlated with hLINE concentration in saliva than in plasma. Conclusion: In our orthotopic model, salivary ctDNA better reflected tumor development and recurrence than did plasma ctDNA.
机译：目的：评价唾液循环肿瘤DNA（CTDNA）作为转移或颈部癌症（HNC）小鼠模型的转移或复发的生物标志物的可行性。 材料和方法：开发了舌癌切除后复发或转移的鼠标模型。 在基线上收集血液和唾液，并在复发或转移时收集。 进行实时聚合酶链反应以定量样品中的人长散射元素（HLINE）以评估CTDNA的量。 结果：在我们的模型中，唾液HLINE随着癌症在手术后发育和减少而增加。 转移小鼠中血浆Hline显着升高。 小鼠中舌癌复发的存在与唾液中的Hline浓度更相关，而不是血浆。 结论：在我们的原位模型中，唾液CTNA更好地反映肿瘤发育和复发性比血浆CTDNA。

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