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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Clinical Influence of Anastomotic Leakage on Esophageal Cancer Survival and Recurrence
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Clinical Influence of Anastomotic Leakage on Esophageal Cancer Survival and Recurrence

机译:吻合口渗漏对食管癌存活和复发的临床影响

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摘要

Background: We investigated the clinical influence of anastomotic leak (AL) on esophageal cancer survival and recurrence after curative surgery. Patients and Methods: This study included 122 patients who underwent curative surgery for esophageal cancer between 2008 and 2018. The patients were classified into those with AL and those without. The risk factors for overall (OS) and recurrence-free (RFS) survival were identified. Results: AL was found in 44 out of the 122 patients (36.1%). The respective OS rates at 3 and 5 years after surgery were 43.9% and 40.2% in the AL group and 63.9% and 53.2% in the non-AL group, which were significantly different (p=0.0049). In contrast, the respective RFS rates at 3 and 5 years after surgery were 44.8% and 29.8%, and 44.9% and 42.4%, which were not significantly different (p=0.2306). A multivariate analysis showed that AL was a significant independent risk factor for both poorer OS and RFS in patients who underwent curative surgery for esophageal cancer. Conclusion: To improve survival of patients with esophageal cancer, the surgical procedure, perioperative care and surgical strategy must be carefully planned in order to prevent AL.
机译:背景:我们调查了吻合泄漏(Al)对食管癌存活率和疗法复发的临床影响。患者及方法:本研究包括2008年至2018年间食管癌治疗手术的122名患者。患者被分类为al和那些没有的人。确定了总体(OS)和无复发(RFS)存活的危险因素。结果:Al在122名患者中的44名(36.1%)中发现。在手术后3和5年的各自的OS率为Al组的43.9%和40.2%,非Al组中的63.9%和53.2%,显着不同(P = 0.0049)。相比之下,手术后3和5年的各自的RFS率为44.8%和29.8%,44.9%和42.4%,没有显着差异(P = 0.2306)。多变量分析表明,Al是对食管癌治疗手术的患者较差的OS和RFS的显着独立的危险因素。结论:为了改善食管癌患者的存活,必须仔细计划手术手术,围手术术和外科策略,以防止al。

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