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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >High Expression of c-Met, PKC lambda and ALDH1A3 Predicts a Poor Prognosis in Late- stage Breast Cancer
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High Expression of c-Met, PKC lambda and ALDH1A3 Predicts a Poor Prognosis in Late- stage Breast Cancer

机译：C-Met的高表达，PKC Lambda和Aldh1a3预测晚期乳腺癌预后差

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Background/Aim: Co-expression of c-Met and ALDH1A3 indicates a poor prognosis in stage III-IV breast cancers and contributes to cell proliferation and tumor formation by ALDH1-positive breast CSCs. PKC lambda is overexpressed and contributes to a poor prognosis in several cancers. Materials and Methods: A breast cancer genomics data set (METABRIC, n=2509) was downloaded and analyzed, as was the effect c-Met and PKC lambda inhibitors on ALDH1(high) cell viability and tumor-sphere formation. Results: c-Met expression correlates with expression of PKC lambda in breast cancer. Stage III-IV breast cancer patients with c-Met(high) PKC lambda(high) ALDH1A3(high) have a poorer prognosis than patients with c-Met(low) PKC lambda(low) ALDH1A3(low). Foretinib and auranofin suppressed cell viability and tumor-sphere formation by ALDH1(high) cells. These results suggest that c-Met and PKC lambda are cooperatively involved in cancer progression and contribute to poor prognoses in breast cancer. Conclusion: c-Met and PKC lambda are potentially useful prognostic markers and therapeutic targets in late-stage breast cancer.
机译：背景/目的：C-Met和Aldh1a3的共表达表明III-IV阶段乳腺癌预后差，有助于通过Aldh1阳性乳腺CSC的细胞增殖和肿瘤形成。 PKC Lambda已经过表达，有助于几种癌症的预后差。材料和方法：下载并分析乳腺癌基因组学数据集（元质，N = 2509），如Aldh1（高）细胞活力和肿瘤 - 球形形成的效果C-Met和PKCλ抑制剂。结果：C-Met表达与乳腺癌中PKCλ的表达相关。 III-IV阶段乳腺癌患者C-Met（高）PKCλ（高）Aldh1a3（高）的预后较差，而不是C-Met（低）PKCλ（低）Aldh1a3（低）的患者。 Foretinib和Auranofin抑制细胞活力和通过Aldh1（高）细胞形成的肿瘤球形形成。这些结果表明，C-Met和PKC Lambda合作涉及癌症进展，并对乳腺癌的贫困预期有助于差。结论：C-Met和PKC Lambda可能是晚期乳腺癌中有用的预后标志物和治疗靶标。

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