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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Effects of Alkalization Therapy on Chemotherapy Outcomes in Metastatic or Recurrent Pancreatic Cancer
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Effects of Alkalization Therapy on Chemotherapy Outcomes in Metastatic or Recurrent Pancreatic Cancer

机译：碱化治疗对转移或复发性胰腺癌化疗结果的影响

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Background/Aim: The acidic tumor microenvironment is associated both with the progression and drug resistance of cancer. We aimed to investigate the effects of alkalization therapy performed concurrently with chemotherapy on the survival of advanced pancreatic cancer patients (study registration: UMIN 000035659). Patients and Methods: Twenty-eight patients with metastatic or recurrent pancreatic cancer were assessed in this study. Alkalization therapy consisted of an alkaline diet with supplementary oral sodium bicarbonate (3.0-5.0 g/day). Results: The mean urine pH was significantly higher after the alkalization therapy (6.85 +/- 0.74 vs. 6.39 +/- 0.92; p 7.0) was significantly longer than those with low urine pH (<= 7.0) (16.1 vs. 4.7 months; p<0.05). Conclusion: An alkalization therapy may be associated with better outcomes in advanced pancreatic cancer patients treated with chemotherapy.
机译：背景/目的：酸性肿瘤微环境与癌症的进展和耐药性有关。 我们旨在探讨碱化治疗的影响同时进行化疗对先进的胰腺癌患者的存活（研究登记：UMIN 000035659）。 患者和方法：在本研究中评估了28例转移性或复发性胰腺癌患者。 碱化疗法由碱性饮食组成，含有补充口服碳酸氢钠（3.0-5.0克/天）。 结果：碱化治疗后平均尿液pH值显着高（6.85 +/- 0.74与6.39 +/- 0.92; p 7.0）显着长于低尿pH（<= 7.0）（16.1节，4.7个月） ; p <0.05）。 结论：碱化治疗可能与化疗治疗的晚期胰腺癌患者更好的结果有关。

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