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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Can Diagnostic Low-dose Whole-body CT Reflect Bone Marrow Findings in Systemic Mastocytosis?
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Can Diagnostic Low-dose Whole-body CT Reflect Bone Marrow Findings in Systemic Mastocytosis?

机译：可以诊断低剂量全身CT反映全身乳细胞症的骨髓发现吗？

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Background/Aim: Systemic mastocytosis (SM) is a heterogeneous hematological entity, characterized by the proliferation of mast cells, commonly involving the skeleton. The present study sought to elucidate whether the computed tomographic (CT) number as Hounsfield units (HU) derived from whole-body CT is associated with bone marrow findings in SM. Patients and Methods: Patient records of the local Oncology and Hematology Department from 2007 to 2018 were screened for patients with SM. Total 16 patients [five female (31.2%)] with a mean age of 55.7 +/- 10.3 years were included in the present retrospective study. KIT mutation; tryptase, alkaline phosphatase, and calcium level in serum; and the proportion of mast cells, and CD2, CD25- and CD117-positive cells in bone marrow biopsies were evaluated. Results: HU correlated with serum calcium level (r=-0.51, p=0.04), mast cell proportion (r=0.66, p=0.01) and with the proportion of CD117-positive cells in bone marrow biopsy (r=0.56, p=0.04). In the group with aggressive SM, the mean HU value was statistically significantly higher than that of the indolent title:group [245 +/- 127 (range=100-451) vs. 121 +/- 16 (range=90-135), respectively, p=0.04]. Conclusion: The present study identified that the HU value derived from low-dose CT was associated with mast cell infiltration in bone marrow in SM and with the proportion of CD117-positive cells. Further studies are needed to determine whether the measurement of the HU value has prognostic implications in SM and can be used as a reliable biomarker in this disease.
机译：背景/目的：全身性乳细胞症（SM）是一种异质血液实体，其特征在于肥大细胞的增殖，通常涉及骨架。本研究试图阐明计算的断层（CT）数量是否源自全体CT的Hounsfield单元（Hu）与SM中的骨髓结果相关。患者及方法：筛选患者患者的患者记录2007至2018年，筛选了SM患者的患者。总计16名患者[五个女性（31.2％）]，平均年龄为55.7 +/- 10.3岁，包括在本回顾性研究中。套件突变;血清胰蛋白酶，碱性磷酸酶和钙水平;并评估肥大细胞的比例和骨髓活组织检查中的CD2，CD25-和CD117阳性细胞。结果：Hu与血清钙水平相关（r = -0.51，p = 0.04），肥大细胞比例（r = 0.66，p = 0.01），并在骨髓活检中的CD117阳性细胞比例（r = 0.56，p = 0.04）。在具有侵略性SM的组中，平均HU值统计学显着高于惰性标题：组[245 +/- 127（范围= 100-451）与121 +/- 16（范围= 90-135）分别p = 0.04]。结论：本研究发现，源自低剂量CT的HU值与SM骨髓中的肥大细胞浸润和CD117阳性细胞的比例相关。需要进一步的研究来确定HU值的测量是否具有SM的预后意义，并且可以用作这种疾病的可靠生物标志物。

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