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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Expression Level of MicroRNA-449a Predicts the Prognosis of Patients With Gastric Cancer
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Expression Level of MicroRNA-449a Predicts the Prognosis of Patients With Gastric Cancer

机译：MicroRNA-449a的表达水平预测胃癌患者的预后

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Background: In previous studies, we demonstrated the significant role of microRNA-449a (miR-449a) in colorectal cancer with in vivo and clinical samples. The importance of miR-449a in gastric cancer is still to be elucidated. This study examined the impact of miR-449a expression in tumor tissue and serum and investigated its potential as a prognostic marker in gastric cancer. Materials and Methods: Sixty-six patients with gastric cancer who underwent surgery were included in the study. miR-449a expression in tumor tissue and serum were investigated by real-time polymerase chain reaction analysis. The association of miR-449a expression with clinicopathological factors and patient prognosis were also investigated. Results: miR-449a expression was lower in tumor tissue than non-tumor tissue. miR-449a in tumor tissue negatively correlated with the malignancy of tumor and clinical stage. Increased carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 ( CA19-9) levels were seen at significantly higher frequencies in patients with low miR-449a expression. Patients with low miR-449a expression had poorer cancerspecific survival compared to those with high miR-449a expression. The univariate analysis showed that lymphovascular invasion, increased CEA and CA19-9 and a low expression of miR-449a were associated with a poorer 5-year cancer-specific survival. miR-449a expression level in serum correlated to that in tumor tissue and was also associated with tumor malignancy. Conclusion: The miR449a level in tumor tissue might be useful as a prognostic indicator for patients with gastric cancer and miR-449a in serum appears to reflect its expression in tumor tissue.
机译：背景：在先前的研究中，我们在体内和临床样品中展示了MicroRNA-449a（miR-449a）在结肠直肠癌中的显着作用。 miR-449a在胃癌中的重要性仍在阐明。该研究检测了miR-449a表达在肿瘤组织和血清中的影响，并研究了胃癌中的预后标志物的潜力。材料和方法：研究六十六名接受手术的胃癌患者。通过实时聚合酶链反应分析研究了肿瘤组织和血清中的miR-449a表达。还研究了miR-449a表达与临床病理因子和患者预后的关联。结果：MiR-449A表达比非肿瘤组织肿瘤组织较低。肿瘤组织中的miR-449a与肿瘤和临床阶段的恶性肿瘤呈负相关。在低miR-449a表达患者的患者中，在显着较高的频率下观察到增加的癌胚抗原（CEA）和碳水化合物抗原19-9（CA19-9）水平。患有低miR-449a表达的患者与具有高miR-449a表达的人相比具有较差的癌变生存率。单变量分析显示，淋巴血管侵袭，增加的CEA和CA19-9和MIR-449A的低表达与较差的5年癌症特异性存活相关。血清中的miR-449a表达水平与肿瘤组织中的血清相关，也与肿瘤恶性肿瘤有关。结论：肿瘤组织中的miR449a水平可用作胃癌患者的预后指标，血清中的miR-449a似乎反映了其在肿瘤组织中的表达。

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