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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Prognostic Value of p16 Protein in Patients With Surgically Treated Non-small Cell Lung Cancer; Relationship With Ki-67 and PD-L1
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Prognostic Value of p16 Protein in Patients With Surgically Treated Non-small Cell Lung Cancer; Relationship With Ki-67 and PD-L1

机译：P16蛋白在手术治疗非小细胞肺癌患者中的预后价值; 与KI-67和PD-L1的关系

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Background/Aim: Non-small cell lung cancer (NSCLC) is the leading cause of cancer death. Patients eligible for surgery have better overall survival rate than patients who are not eligible. We investigated the prognostic value of p16 in patients who underwent surgery for lung cancer, in association with other factors such as PD-L1 and Ki-67. Materials and Methods: Expression of p16 was evaluated along with the presence of Ki-67 and PD-L1 in 256 NSCLC patients treated only surgically. Results: Adenocarcinoma was the prevalent histotype (56%) followed by squamous cell (29%) and differentiation grade of 3 was the most common (60%). p16 was detected in 83 patients (30%): low positivity ( 10 % cells) in 53 patients (20%). Ki-67 was detected in 89 patients (34%) with mild positivity in 46 patients (10-25% cells), moderate positivity (26-75% cells) in 30 patients (11%), and high positivity (>75% cells) in 13 patients (5%). An influence of p16 expression (p < 0.05) along with grading and staging on overall survival (OS) was found. The average OS was 36 months, but the OS increased up to 54 months when patients were stratified according to p16 expression levels. The stratification by staging showed a significant prognostic value for p16 at an early stage (p < 0.014). Conclusion: p16 significantly influences prognosis, notably at an early stage, along with other variables such as grading and staging.
机译：背景/目的：非小细胞肺癌（NSCLC）是癌症死亡的主要原因。有资格进行手术的患者比不符合条件的患者具有更好的整体生存率。我们研究了P16的预后价值，接受肺癌手术的患者，与PD-L1和KI-67等其他因素相关联。材料和方法：评估P16的表达以及256例NSCLC患者的KI-67和PD-L1的存在，仅在手术治疗。结果：腺癌是普遍的组织型（56％），然后是鳞状细胞（29％），分化级别3级最常见（60％）。在83名患者中检测到P16（30％）：53名患者（20％）的低阳性（10％细胞）。在89名患者（34％）中检测到KI-67，在46名患者（10-25％的细胞）中，中度阳性（26-75％细胞），在30名患者（11％）和高阳性（> 75％）细胞）13名患者（5％）。发现P16表达（P <0.05）的影响以及整体存活（OS）的分级和分期。平均OS为36个月，但根据P16表达水平分层分层时，OS增加了54个月。通过分期的分层显示出在早期p16的显着预后值（P <0.014）。结论：P16显着影响预后，特别是在早期阶段，以及其他变量，如分级和分期。

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