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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Bone Mineral Density as a Potential Predictive Factor for Luminal-type Breast Cancer in Postmenopausal Women
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Bone Mineral Density as a Potential Predictive Factor for Luminal-type Breast Cancer in Postmenopausal Women

机译：骨矿物质密度作为绝经后患者腔式乳腺癌的潜在预测因素

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Background/Aim: We performed a case-control study to evaluate whether bone mineral density (BMD) can be considered a potential predictive factor for luminal-type breast cancer (BC), that could be useful in constructing a predictive risk model. Materials and Methods: The medical records of 297 postmenopausal women with luminal-type node-negative BC who underwent lumbar-spine dual-energy X-ray absorptiometry (DXA) with BMD measurement before surgery, were analyzed and compared with those of 297 age-matched randomly selected healthy controls. The correlations between women's reproductive history, including the age at menarche and menopause, parity, oral contraceptives and hormone replacement therapy (HRT) use, the results of DXA, and BC risk were evaluated in univariate and multivariate analyses. Results: Overall, 168 (28.3%) women had osteoporosis and/or osteopenia (low BMD). Both bone alterations were protective factors for BC, especially when they were considered together (p=0.001). Only the interval between menarche and menopause (MMI), dichotomized at 37.5 years as an optimal cut-off and the HRT use reached a statistical significance (p0.01) as risk factors. The three parameters were independent because they remained significant in the stepwise logistic regression analysis. The area under the receiver operating characteristic (ROC) curve (AUC) obtained with the model was 0.694 (95%CI=0.694-0.731). Conclusion: This hypothesized predictive model is fairly accurate and could identify patients at increased risk of developing luminal-type BC in a population of postmenopausal women who performed DXA, simply based on their history.
机译：背景/目的：我们进行了案例对照研究以评估骨矿物密度（BMD）是否可以被认为是腔式乳腺癌（BC）的潜在预测因素，这对于构建预测风险模型可能是有用的。材料和方法：分析并在手术前接受了腰椎型节点阴性BC的297例绝经后妇女的医学记录，并与BMD测量进行了手术前的患者，并与297岁匹配随机选择的健康控制。在单变量和多变量分析中，评估了女性生殖史，包括月经初潮和更年期的年龄，包括年龄，阶段，床位，口服避孕药和激素替代疗法（HRT）的使用情况，在单变量和多变量分析中评估了DXA的结果和BC风险。结果：总体而言，168名（28.3％）妇女患有骨质疏松症和/或骨质增长（低BMD）。骨骼改变都是BC的保护因子，特别是当它们被认为是在一起时（p = 0.001）。只有37.5岁的淫荡和更年期（MMI）之间的间隔只有37.5岁作为最佳截止，并且HRT使用达到统计学意义（P <0.01），为风险因素。三个参数是独立的，因为它们在逐步逻辑回归分析中保持显着。使用该模型获得的接收器操作特征（ROC）曲线（AUC）下的区域为0.694（95％CI = 0.694-0.731）。结论：这种假设的预测模型相当准确，可识别患者在进行DXA的绝经后妇女患者中培养腔型BC的风险增加，简单地基于他们的历史。

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