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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Circulating Pre-microRNA-488 in Peripheral Blood Is a Potential Biomarker for Predicting Recurrence in Breast Cancer
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Circulating Pre-microRNA-488 in Peripheral Blood Is a Potential Biomarker for Predicting Recurrence in Breast Cancer

机译：在外周血中循环microRNA-488是一种潜在的生物标志物，用于预测乳腺癌中的复发

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Background/Aim: Circulating microRNAs (miRs) in blood have been highlighted as diagnostic, prognostic and predictive biomarkers for "Precision medicine". This study aimed to explore the possibility of using circulating precursor miRs (pre-miRs) as clinical biomarkers of recurrence in breast cancer. Materials and Methods: We performed miR microarray analyses of circulating miRs in blood from patients with or without recurrence of breast cancer and identified miR-488-5p as a recurrence-related miR. Then, the expression levels of pre-miR-488 or miR-488-5p were measured by RT-qPCR and the clinicopathological and prognostic significance of circulating pre-miR-488 was assessed in the blood of breast cancer patients. Results: A positive correlation was noted between pre-miR-488 and miR-488-5p expression in blood. In 330 cases of surgically-treated breast cancer, high expression of circulating pre-miR-488 was an independent poor prognostic factor for recurrence free survival. Conclusion: Circulating pre-miR-488 expression could be a novel prognostic biomarker for predicting recurrence in breast cancer patients.
机译：背景/目的：血液中的循环microRNA（MIRS）被强调为“精密药物”的诊断，预测和预测生物标志物。本研究旨在探讨使用循环前体MIR（前MIR）作为乳腺癌复发的临床生物标志物的可能性。材料和方法：我们对患有乳腺癌或不复发的患者的血液循环miR进行了MIR微阵列分析，并确定了miR-488-5p作为复发相关的miR。然后，通过RT-QPCR测量miR-488或miR-488-5p的表达水平，并在乳腺癌患者的血液中评估循环前尿-488的临床病理和预后意义。结果：在血液中的miR-488和miR-488-5p表达之间注意到阳性相关性。在330例外科医疗乳腺癌中，循环前MIR-488的高表达是一种独立的自由存活预后因素。结论：循环miR-​​488表达可能是一种用于预测乳腺癌患者复发的新型预后生物标志物。

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