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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >The Role of Soluble CD40L Ligand in Human Carcinogenesis
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The Role of Soluble CD40L Ligand in Human Carcinogenesis

机译：可溶性CD40L配体在人致癌中的作用

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Background: The role of CD40/CD40L in carcinogenesis is widely examined. The mechanisms linking the CD40/CD40L system and the soluble form of CD40 ligand (sCD40L) with neoplasia are nowadays a topic of intensive research. CD40L and sCD40L belong to the TNF superfamily and are molecules with a proinflammatory role. A variety of cells express CD40L such as the immune system cells, the endothelial cells and activated platelets. Although many medications such as statins have been shown to reduce sCD40L, it is still debated whether specific treatments targeting the CD40/CD40L system will prove to be effective against carcinogenesis in the near future. Materials and Methods: A comprehensive search of the Pubmed Database was conducted for English-language studies using a list of key words. Results: At diagnosis, serum samples of patients with neoplasia contained higher levels of sCD40L than healthy controls, suggesting that sCD40L may play a predictive role in human carcinogenesis. Conclusion: Patients with neoplasia had higher circulating sCD40L levels and it is likely that sCD40L may have a predictive role. It is still unclear whether sCD40L can be used as a therapeutic target.
机译：背景：广泛检查CD40 / CD40L在癌发生中的作用。将CD40 / CD40L系统和可溶性CD40配体（SCD40L）与肿瘤的可溶形式的机制如今是一个密集研究的主题。 CD40L和SCD40L属于TNF超家族，是具有促炎作用的分子。各种细胞表达CD40L，例如免疫系统细胞，内皮细胞和活性血小板。虽然已经证明了许多等药物，但已被证明减少SCD40L，但仍讨论靶向CD40 / CD40L系统的特异性治疗是否将在不久的将来持续对癌生成有效。材料和方法：使用关键词列表进行英语研究进行了全面搜索PubMed数据库。结果：在诊断中，肿瘤患者的血清样本含有较高水平的SCD40L，而不是健康的对照，表明SCD40L可能在人类致癌中发挥预测作用。结论：肿瘤患者具有更高的循环SCD40L水平，很可能是SCD40L可能具有预测的作用。尚不清楚SCD40L是否可以用作治疗目标。

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