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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >The Frequency and Prognostic Value of Neutrophilia in Chronic Lymphocytic Leukemia
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The Frequency and Prognostic Value of Neutrophilia in Chronic Lymphocytic Leukemia

机译：慢性淋巴细胞白血病中性粒细胞粒细胞的频率和预测值

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Background/Aim: In chronic lymphocytic leukemia (CLL) the absolute neutrophil count (ANC) has generally been reported to be within normal limits and leukocytosis is due to absolute lymphocytosis. However, other cell types such as neutrophils and monocytes may also exceed the normal range in this disorder. The aim of this retrospective study was to evaluate the frequency and prognostic value of neutrophilia defined as an ANC7x 10(9)/l and monocytosis- an absolute monocyte count (AMC)1x 10(9)/l in 113 patients with chronic lymphocytic leukemia (CLL). Materials and Methods: We analyzed clinical and laboratory data from the records of patients with CLL followed in the Hematology unit of a tertiary hospital in Israel. Patients were categorized according to their ANC and AMC before treatment and their data compared. Results: In 24 (21%) patients, neutrophilia was present at diagnosis while 40 (35%) had monocytosis. We identified that 9% of cases had neutrophilia with normal AMC. This subgroup of patients had a better prognosis with lower mortality rate, longer time-to-treatment interval and a higher rate of complete or partial response to treatment compared to patients without neutrophilia or monocytosis. Conclusion: The presence of neutrophilia without monocytosis before treatment appears to be associated with a more favorable prognosis in CLL. These observations still need to be confirmed and validated in a larger cohort of patients.
机译：背景/目的：在慢性淋巴细胞白血病（CLL）中，通常据报道，绝对中性粒细胞计数（ANC）在正常限制内，白细胞增多是由于绝对淋巴细胞增强。然而，其他细胞类型如中性粒细胞和单核细胞也可能超过该病症中的正常范围。该回顾性研究的目的是评估中性粒细胞菌定义为ANC＆GT的频率和预后值。7×10（9）/ L和单胞菌症 - 一种绝对单核细胞计数（AMC）＆ 1×10（9）/ L在113名患者中用慢性淋巴细胞白血病（CLL）。材料和方法：我们分析了来自CLL患者的临床和实验室数据，随后在以色列的一家高等院医院的血液学单元中遵循。患者在治疗之前根据他们的ANC和AMC进行分类，并比较它们的数据。结果：24例（21％）患者，中性粒细胞症存在于诊断时存在，而40（35％）有单胞萝卜。我们认为9％的病例有患有正常AMC的中性粒细胞菌。这种患者的亚组具有更好的预后，死亡率较低，时间较长的时间间隔，与没有中性粒细胞或单胞菌肤的患者相比治疗的较高速度或对治疗的更高速度。结论：在治疗前没有单键分子的嗜中性粒细胞瘤的存在似乎与CLL更有利的预后相关。这些观察仍需要在较大的患者队列中确认和验证。

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