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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Cannabinoid Receptor-1 Up-regulation in Azoxymethane (AOM)-treated Mice After Dietary Treatment with Quercetin
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Cannabinoid Receptor-1 Up-regulation in Azoxymethane (AOM)-treated Mice After Dietary Treatment with Quercetin

机译：大麻素受体-1亚辛酰亚胺甲烷（AOM）的上调 - 治疗槲皮素膳食处理后的小鼠

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摘要

Background/Aim: The expression of cannabinoid receptor-1 (CB1-R)seems to be modulated by bioactive natural components such as the flavonoid quercetin. The aim of this study was to determine in an animal model of induced-colon cancer, whether quercetin inhibits colon carcinogenesis through changes in the expression of CB1-R. Materials and Methods: C57BL/6J male mice were randomly assigned to standard diet or experimental diet supplemented with 0.5% quercetin. Azoxymethane (AOM) (10 mg/kg body weight) or saline solution (PBS) was intraperitoneally injected, once weekly for 6 weeks. Results: The diet supplemented with quercetin induced CB1-Rgene expression and protein, inhibiting the protein levels of STAT3 and p-STAT3 (both mediators of cell proliferation). Dietary quercetin also caused a significant increase in Bax/Bcl2 ratio protein expression. Conclusion: The anti-proliferative and pro-apoptotic effects of quercetin in ADM-treated mice are mediated by induction of the protein and gene expression levels of CB1-R.
机译：背景/目的：大麻素受体-1（CB1-R）的表达似乎通过生物活性天然成分（例如类黄酮槲皮素）调节。本研究的目的是在诱导 - 结肠癌的动物模型中确定槲皮素是否抑制CB1-R表达的变化。材料和方法：C57BL / 6J雄性小鼠随机分配给补充0.5％槲皮素的标准饮食或实验饮食。偶氮酰胺（AOM）（10mg / kg体重）或盐水溶液（PBS）腹膜内注射一次，每周一次6周。结果：补充槲皮素诱导CB1-RGENE表达和蛋白质的饮食，抑制STAT3和P-STAT3（细胞增殖的两种介质）的蛋白质水平。膳食槲皮素还导致BAX / BCL2比例蛋白表达显着增加。结论：通过诱导CB1-R的蛋白质和基因表达水平来介导槲皮素在Adm-propered小鼠中的抗增殖和促凋亡作用。

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