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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Chitinase-3-like Protein 1 (YKL-40) Expression in Squamous Cell Skin Cancer
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Chitinase-3-like Protein 1 (YKL-40) Expression in Squamous Cell Skin Cancer

机译：Chitinase-3样蛋白1（YKL-40）在鳞状细胞皮肤癌中表达

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Background/Aim: YKL-40 plays a role in proliferation and differentiation of malignant cells. The aim of this study was to examine whether YKL-40 is expressed in cutaneous squamous cell carcinoma (SCC). Materials and Methods: The study was based on histologically-confirmed biopsies of cutaneous SCCs obtained from 38 patients. The tissue expression of YKL-40 was assessed using an immunohisto-chemical method. The percentage of cells showing a positive reaction as well as the intensity of the IHC reaction was assessed using the immunoreactive score developed by Remmele and Stegner. Results: All samples of cutaneous SCCs showed cytoplasmic expression of YKL-40. The intensity of YKL-40 expression varied between 1 and 8 points, according to the applied scale. In the majority of cancers about 10-80% of tumor cells were positive for YKL-40. The intensity of the reaction was low (20 samples, 52.6%) or medium (18 samples, 47.4%). Conclusion: YKL-40 is expressed in cutaneous SCC. Further research is needed to establish the value of YKL-40 for diagnosis and monitoring of SCC.
机译：背景/目的：YKL-40在恶性细胞的增殖和分化中起作用。本研究的目的是检查YKL-40是否以皮肤鳞状细胞癌（SCC）表示。材料和方法：该研究基于从38名患者获得的皮肤SCC的组织学证实的活组织检查。使用免疫组化学法评估YKL-40的组织表达。使用Remmele和Stegner开发的免疫反应评分评估显示阳性反应的细胞的百分比以及IHC反应的强度。结果：所有皮肤SCC样品显示YKL-40的细胞质表达。根据所施加的比例，YKL-40表达的强度在1至8点之间变化。在大多数癌症中，约10-80％的肿瘤细胞对于YKL-40是阳性的。反应强度低（20样品，52.6％）或培养基（18个样品，47.4％）。结论：YKL-40在皮肤SCC中表达。需要进一步的研究来建立YKL-40的诊断和监测SCC的价值。

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