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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Modified Nucleosides - Molecular Markers Suitable for Small-volume Cancer? PHILIPP
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Modified Nucleosides - Molecular Markers Suitable for Small-volume Cancer? PHILIPP

机译：改性核苷类 - 适用于小体积癌的分子标记？ 菲利普

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Background: Modified nucleosides (mNS) in urine are shown to be encouraging markers in cancer, mostly in patients presenting with high tumor mass such is breast and lung cancer. To our knowledge, mNS have not been investigated in head and neck squamous cell carcinoma (HNSCC). HNSCC is characterized by early metastasis into locoregional lymph nodes and slow infiltrating growth, but even in the advanced stage exhibits only a relatively low cancer volume. Therefore, reliable distinction between HNSCC and healthy controls by urinary mNS might pose substantial analytical problems and even more as patients with HNSCC mostly have an increased exposure to tobacco smoke and excessive alcohol consumption which affect the renal mNS pattern. Materials and Methods: Urinary mNS in samples of 93 therapy-naive patients with HNSCC and 242 healthy controls were quantified by reversedphase high-performance liquid chromatography. Considering that the circadian rhythm causes diuresis-induced variations in concentration, the mNS-to-creatinine ratio was chosen to compare patients and controls. For sensitivity and specificity in discriminating between patients and controls, the corresponding curve was plotted. Additionally, logistic regression was carried out and a multilayer perceptron neuronal network (NN) was created. Results: Fifteen mNS were detectable in cases and controls; concentrations of 11 were found to be significantly different. The sensitivity and specificity depend on the total volume of the lesion; HNSCC with volume 20 ml was reliably detected, but those with a volume of 20 ml or greater produced amounts of mNS which led to the most accurate detection of HNSCC based on HNSCC-specific mNS patterns. Conclusion: Analysis of urinary mNS allows for detection of small-volume HNSCC, with acceptable specificity and sensitivity if the tumor volume exceeds 20 ml.
机译：背景：尿液中的修饰核苷（MNS）被证明是令癌症中的标志物，主要是患有高肿瘤质量的患者，如乳腺癌和肺癌。据我们所知，尚未在头部和颈鳞状细胞癌（HNSCC）中进行MNS。 HNSCC以早期转移的特征在于进入型淋巴结和缓慢的渗透生长，但即使在晚期阶段也表现出相对低的癌症体积。因此，HNSCC和尿MNS的健康对照之间的可靠区分可能会造成大量分析问题，并且随着HNSCC的患者大多是增加暴露于影响肾MNS模式的烟草烟雾和过量的醇消耗。材料和方法：通过逆转相高性能液相色谱法量化了93例治疗 - 幼稚患者的93例治疗 - 幼稚患者样品中的尿MNS。考虑到昼夜节律导致利尿症诱导的浓度变化，选择MNS致肌酸酐比率比较患者和对照。为了鉴别患者和对照之间的敏感性和特异性，绘制了相应的曲线。另外，进行了物流回归，并创建了多层的感知性神经元网络（NN）。结果：在病例和对照中可检测到15米MNS;发现11个浓度显着不同。敏感性和特异性取决于病变的总体积;具有体积＆ 20ml的HNSCC可靠地检测，但具有20mL或更高产生的MN的那些，其基于HNSCC特定的MNS图案导致HNSCC最精确地检测HNSCC。结论：尿液MNS分析允许检测小体积HNSCC，如果肿瘤体积超过20mL，则具有可接受的特异性和敏感性。

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