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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Tumor Budding Versus Mismatch Repair Status in Colorectal Cancer - An Exploratory Analysis
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Tumor Budding Versus Mismatch Repair Status in Colorectal Cancer - An Exploratory Analysis

机译：肿瘤萌芽与结直肠癌中的不匹配修复状态 - 探索性分析

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Background: Tumor budding and a proficient mismatch repair (pMMR) status are considered adverse prognostic factors in colorectal cancer (CRC). The aim of this pilot study was to assess tumor budding in primary CRC with pMMR versus that with deficient mismatch repair (dMMR). Materials and Methods: Tumor budding was retrospectively examined in the tumor from 134 patients with stage II and stage III CRC with known MMR status. The 29 available dMMR cases who developed recurrence or distant metastases (met+) were matched with a dMMR group with no recurrence or metastases (met-), and the pMMR/met+ group with pMMR/met- cases. Results: Using tumor budding cut-offs of 5 and 10, a significantly higher percentage of high-grade tumor budding (= 5 and = 10) was only found in the dMMR/met+ compared to pMMR/met+ subgroup (p=0.01 and p=0.02, respectively). Conclusion: A significantly higher grade of tumor budding was observed in the dMMR/met+ group, suggesting that tumor budding can provide prognostic information for patients with a dMMR status.
机译：背景：肿瘤萌芽和熟练失配修复（PMMR）状态被认为是结直肠癌（CRC）中的不良预后因素。该试点研究的目的是评估初级CRC的肿瘤芽，PMMR与不缺差修复（DMMR）的影响。材料和方法：从134例II阶段和III级CRC患者中回顾性地检查肿瘤芽面，患有已知的MMR状态。发育复发或远处转移（MET +）的可用DMMR病例与DMMR组匹配，没有复发或转移（MET-），以及具有PMMR / MET的PMMR / MET +组。结果：使用5和10的肿瘤芽截止，高级肿瘤芽（＆ = 5和 = 10）显着提高百分比。与PMMR / MET +亚组相比仅在DMMR / MET +中发现（P.分别= 0.01和p = 0.02）。结论：在DMMR / MET +组中观察到肿瘤芽等得分明显高，表明肿瘤芽可以为DMMR地位提供预后信息。

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