Controlling Nutritional Status (CONUT) Score Is a Prognostic Marker in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy

Daitoku Nobuya; Miyamoto Yuji; Tokunaga Ryuma; Sakamoto Yuki; Hiyoshi Yukiharu; Iwatsuki Masaaki; Baba Yoshifumi; Iwagami Shiro; Yoshida Naoya; Baba Hideo

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Controlling Nutritional Status (CONUT) Score Is a Prognostic Marker in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy

机译：控制营养状况（Conut）评分是接受一线化疗的转移结直肠癌患者的预后标志物

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Background/Aim: The Controlling Nutritional Status (CONUT) score is a useful nutritional evaluation, that is calculated from serum albumin, total cholesterol concentrations, and total lymphocyte count. This study aimed to investigate the association between the CONUT score and prognosis in patients with metastatic colorectal cancer (mCRC). Patients and Methods: The CONUT score was retrospectively calculated in 211 patients with mCRC receiving first-line chemotherapy. The patients were divided into three groups: the CONUT low-group (0-1), intermediate-group (2-4), and high-group (5-). The associations of the CONUT score with clinicopathological factors and survival outcomes were evaluated. Results: The higher CONUT score was significantly associated with synchronous metastases, and no primary tumor resection. The higher CONUT score group showed a significant shorter progression free survival (log-rank p0.05) and overall survival (log-rank p0.001). Conclusion: The CONUT score is a useful prognostic marker for predicting survival outcomes of patients with mCRC.

机译：背景/目的：控制营养状况（Conut）得分是一种有用的营养评价，其由血清白蛋白，总胆固醇浓度和总淋巴细胞计数计算。本研究旨在探讨转移结直肠癌患者（MCRC）的截止分数和预后之间的关联。患者和方法：在211例MCRC接受一线化疗的211例MCRC患者中回顾性评分。将患者分为三组：Conut低组（0-1），中间组（2-4）和高群（5-）。评估了截止分数与临床病理因子和存活结果的关联。结果：与同步转移显着升高的分数，没有原发性肿瘤切除。较高的康顿素得分组显示出显着的较小进展免疫存活（对数秩P <0.05）和总存活（对数级P <0.001）。结论：Contut评分是一种有用的预后标志物，用于预测MCRC患者的存活结果。

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《Anticancer Research: International Journal of Cancer Research and Treatment》 |2018年第8期|共6页
作者
Daitoku Nobuya; Miyamoto Yuji; Tokunaga Ryuma; Sakamoto Yuki; Hiyoshi Yukiharu; Iwatsuki Masaaki; Baba Yoshifumi; Iwagami Shiro; Yoshida Naoya; Baba Hideo;
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Kumamoto Univ Grad Sch Med Sci Dept Gastroenterol Surg 1-1-1 Honjo Kumamoto 8608556 Japan;

Kumamoto Univ Grad Sch Med Sci Dept Gastroenterol Surg 1-1-1 Honjo Kumamoto 8608556 Japan;

Kumamoto Univ Grad Sch Med Sci Dept Gastroenterol Surg 1-1-1 Honjo Kumamoto 8608556 Japan;

Kumamoto Univ Grad Sch Med Sci Dept Gastroenterol Surg 1-1-1 Honjo Kumamoto 8608556 Japan;

Kumamoto Univ Grad Sch Med Sci Dept Gastroenterol Surg 1-1-1 Honjo Kumamoto 8608556 Japan;

Kumamoto Univ Grad Sch Med Sci Dept Gastroenterol Surg 1-1-1 Honjo Kumamoto 8608556 Japan;

Kumamoto Univ Grad Sch Med Sci Dept Gastroenterol Surg 1-1-1 Honjo Kumamoto 8608556 Japan;

Kumamoto Univ Grad Sch Med Sci Dept Gastroenterol Surg 1-1-1 Honjo Kumamoto 8608556 Japan;

Kumamoto Univ Grad Sch Med Sci Dept Gastroenterol Surg 1-1-1 Honjo Kumamoto 8608556 Japan;

Kumamoto Univ Grad Sch Med Sci Dept Gastroenterol Surg 1-1-1 Honjo Kumamoto 8608556 Japan;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
CONUT score; metastasis; colorectal cancer; prognostic marker;

机译：孵化得分;转移;结肠直肠癌;预后标志物;

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2. Controlling Nutritional Status (CONUT) Score Is a Prognostic Marker in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy [J] . Daitoku Nobuya, Miyamoto Yuji, Tokunaga Ryuma, Anticancer Research: International Journal of Cancer Research and Treatment . 2018,第8期

机译：控制营养状况（Conut）评分是接受一线化疗的转移结直肠癌患者的预后标志物
3. Controlling Nutritional Status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection [J] . Daisuke Kuroda, Hiroshi Sawayama, Junji Kurashige, Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association . 2018,第2期

机译：控制营养状况（Cont）评分是治疗切除后胃癌患者的预后标志物
4. Prognostic Value of BRAF, PI3K, PTEN, EGFR Copy Number, Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy [J] . Llovet Patricia, Sastre Javier, Sanz Ortega Julian, Molecular diagnosis & therapy . 2015,第6期

机译：BRAF，PI3K，PTEN，EGFR拷贝数，双调蛋白和上调蛋白状态在KRAS密码子12野生型转移性大肠癌接受一线化疗联合抗EGFR治疗的患者中的预后价值
5. Is High-Dose Chemotherapy Plus Stem-Cell Transplant the Standard Treatment for Patients Failing First-Line Chemotherapy for Metastatic Germ Cell Tumor? [C] . Christian Kollmannsberger, Lawrence Einhorn, Craig Nichols Genitourinary Cancers Symposium. . 2014

机译：高剂量化疗加干细胞移植对转移细胞肿瘤的一线化疗失败的患者的标准治疗吗？
6. Predictive factors of the treatment outcome in patients with advanced biliary tract cancer receiving gemcitabine plus cisplatin as first-line chemotherapy [D] . 鈴木, 裕子 2019

机译：吉西他滨联合顺铂一线化疗对晚期胆道癌患者治疗效果的预测因素
7. Prognostic Value of Combined Tumor Marker and Controlling Nutritional Status (CONUT) Score in Colorectal Cancer Patients [O] . Manabu Yamamoto, Hiroaki Saito, Chihiro Uejima, 2019

机译：肿瘤标志物联合控制营养状况（CONUT）评分对大肠癌患者的预后价值
8. The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients undergoing resection for colorectal cancer [O] . Tamuro Hayama, Tsuyoshi Ozawa, Yuka Okada, 2020

机译：控制营养状况（Cont）评分的预处理是对结直肠癌切除切除的患者的独立预后因素

Controlling Nutritional Status (CONUT) Score Is a Prognostic Marker in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy

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