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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Effect of Whole-abdominal Irradiation on Penetration Depth of Doxorubicin in Normal Tissue After Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in a Post-mortem Swine Model
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Effect of Whole-abdominal Irradiation on Penetration Depth of Doxorubicin in Normal Tissue After Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in a Post-mortem Swine Model

机译：在验尸型猪疗后型腹腔内施用腹膜气溶胶化疗（PIPAC）在正常组织中对多柔比蛋白渗透深度的影响

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Background: This study was performed to evaluate the impact of whole-abdominal irradiation on local penetration of doxorubicin into the peritoneum and the abdominal organs in a post-mortem swine model. Materials and Methods: Doxorubicin was aerosolized into the abdominal cavity of swine at a pressure of 12 mmHg CO2 at room temperature (25 degrees). One swine was subjected to pressurized intraperitoneal aerosol chemotherapy (PIPAC) using Micropump (c) without irradiation; the second one received 2 Gy and the third one 7 Gy whole-abdominal irradiation, 15 min prior to PIPAC application. Samples of the peritoneal surface were extracted at different positions from within the abdominal cavity. In-tissue doxorubicin penetration was measured using fluorescence microscopy on frozen thin sections. Results: The depth of penetration of doxorubicin was found to be wide-ranging, between 17 mu m on the surface of the stomach and 348 mu m in the small intestine. The penetration depth into the small intestine was 348 mu m, 312 mu m and 265 mu m for PIPAC alone, PIPAC with 2 Gy irradiation and PIPAC with 7 Gy irradiation, respectively (p<0.05). The penetration into the liver was 64 mu m, 55 mu m and 40 mu m, respectively (p= 0.05). Conclusion: Irradiation was not found to increase the depth of doxorubicin penetration into normal tissue in the postmortem swine model. A reduction of doxorubicin penetration was observed after application of higher irradiation doses. Further studies are warranted to determine if irradiation can be used safely as chemopotentiating agent for patients with peritoneal metastases treated with PIPAC.
机译：背景：本研究进行了评估全腹部辐射对杀死后猪疗法的局部渗透到腹膜和腹部器官的影响。材料和方法：在室温（25度）的12mmHg CO 2的压力下，多柔比星在猪的腹腔中雾化到猪的腹腔中。使用Micropump（C）在没有辐射的微型泵（C）的腹膜内气溶胶化疗（PIPAC）对一个猪进行加压;第二个接受了2 GY和第三个7 Gy全腹部照射，在PIPAC应用前15分钟。在腹腔内以不同位置萃取腹膜表面的样品。使用荧光显微镜在冷冻薄部分上测量组织内渗透渗透。结果：发现多柔比星的渗透深度宽范围，胃表面的17μm介于348μm之间。对于单独的PIPAC，PIPAC的渗透深度为348μm，312μm和265μm，分别具有2个gy辐照和铅照射的pipac（p <0.05）。分别渗透到肝脏中，分别为64μm，55μm和40μmm（p = 0.05）。结论：未发现辐照将多柔比星渗透到后型猪水模型中的正常组织深度。在施用较高的照射剂量后观察到在多柔比星渗透的降低。有必要进一步研究以确定是否可以安全地使用潜水剂作为用PIPAC处理的腹膜转移患者的化学监管剂。

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