...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Increased CXCL8 Expression Is Negatively Correlated with the Overall Survival of Patients with ER-Negative Breast Cancer
【24h】

Increased CXCL8 Expression Is Negatively Correlated with the Overall Survival of Patients with ER-Negative Breast Cancer

机译：CXCL8表达的增加与ER阴性乳腺癌患者的整体存活率负相关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: C-X-C motif chemokine ligand 8 (CXCL8) is a multi-functional chemokine and has important roles during tumor formation and development. It was previously reported that increased CXCL8 protein levels occurred in certain patients. Materials and Methods: In the present study, we examined levels of CXCL8 mRNA in breast cancer tissues and analyzed its levels in correlation to patients' clinical data and 10-year overall survival (OS). Results: Our results clearly demonstrated that the level of CXCL8 mRNA was significantly higher in patients without estrogen receptor expression. The receiver operating characteristic curve indicated that the best cut-off value for CXCL8 expression was 3.095 for predicting patient's OS. Conclusion: The present study demonstrated that higher CXCL8 mRNA levels in breast cancer tissues together with estrogen receptor negativity was associated with significantly shorter OS, and could be applied as a negative risk factor for 10-year OS.
机译：背景：C-X-C主题趋化因子配体8（CXCL8）是一种多功能趋化因子，在肿瘤形成和发育过程中具有重要作用。 之前报道，在某些患者中发生了增加的CXCL8蛋白质水平。 材料和方法：在本研究中，我们检查了乳腺癌组织中CXCL8 mRNA的水平，并分析了与患者临床数据和10年整体存活（OS）相关的水平。 结果：我们的结果清楚地证明，没有雌激素受体表达的患者CXCL8 mRNA的水平显着高。 接收器操作特性曲线表明CXCL8表达式的最佳截止值为3.095，用于预测患者的操作系统。 结论：本研究表明，乳腺癌组织中较高的CXCL8 mRNA水平与雌激素受体消极性有关，OS显着较短，可作为10年次OS的负危险因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号