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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Prospective Evaluation of Neuromediator Dynamics in Castration-Resistant Prostate Cancer Patients During Docetaxel
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Prospective Evaluation of Neuromediator Dynamics in Castration-Resistant Prostate Cancer Patients During Docetaxel

机译：多西紫杉醇阉割前列腺癌患者中神经对药剂动力学的前瞻性评价

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Aim: Aim of the study was to detect small cell/neuroendocrine (SCNC) transformation in metastatic castration-resistant prostate cancer (mCRPC) that is a challenging procedure. We investigated the role of neuromediator dynamics as potential evidence of SCNC in patients undergoing docetaxel therapy. Patients and Methods: A multi-institutional, prospective observational study was conducted. Patients undergoing docetaxel treatment were included. Chromogranin A (CGA), neuron-specific enolase (NSE), and pro-gastrin releasing peptide (Pro-GRP) were sequentially evaluated at predefined time points. Outcome measures were overall survival (OS), progression-free survival (PFS) and PSA nadir. Results: Fifty-two patients were included. A general rise in CGA levels was observed. Patients with a high CGA rise (100% ULN: CGA >= 98.1ng/ml) between the 1st and 3rd cycle trended towards a decreased OS (p= 0.0649) and showed a decreased PFS (p= 0.0369). In multivariate analysis, continuous CGA rise correlated with PFS (p= 0.0553; HR 1.136), but was not an independent predictor of OS. Conclusion: Patients with an early high CGA rise may demonstrate a subgroup with poor outcome due to underlying SCNC transformation. Monitoring of CGA appears to be an option worth considering.
机译：目的：该研究的目的是检测抗旋转性抵抗前列腺癌（MCRPC）的小细胞/神经内分泌（SCNC）转化，这是一个具有挑战性的程序。我们调查了神经维蛋白动态的作用作为患有多西紫杉醇治疗的患者SCNC的潜在证据。患者和方法：进行多机构，前瞻性观察研究。包括接受多西紫杉醇治疗的患者。在预定的时间点依次评估依次评估Chormogranin A（CGA），神经元特异性烯醇酶（NSE）和促胃泌素释放肽（PRO-GRP）。结果措施是整体存活（OS），无进展生存（PFS）和PSA Nadir。结果：包括五十二名患者。观察到CGA水平的一般上升。在第1和第3循环之间趋向于降低的OS（P = 0.0649）之间的高CGA升高（100％ULN：CGA> = 98.1ng / ml），并显示出降低的PFS（p = 0.0369）。在多变量分析中，连续CGA上升与PFS相关（P = 0.0553; HR 1.136），但不是OS的独立预测因子。结论：早期高CGA升高的患者可以展示由于潜在的SCNC转化导致的结果差。监测CGA似乎是值得考虑的选择。

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