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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Safety for Repeat Lumpectomy Without Radiotherapy for Ipsilateral Breast Tumor Recurrence
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Safety for Repeat Lumpectomy Without Radiotherapy for Ipsilateral Breast Tumor Recurrence

机译：没有放射治疗的重复肿瘤切除术的安全性，用于同侧乳腺肿瘤复发

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摘要

Background: There is little information on the local recurrence risk of patients who undergo repeat lumpectomy without radiotherapy after salvage surgery for ipsilateral breast tumor recurrence (IBTR). Patients and Methods: Sixty-five patients who underwent repeat lumpectomy without radiotherapy after IBTR were retrospectively analyzed. The risk factors of second IBTR, including the breast cancer subtype of IBTR defined by the estrogen receptor (ER) and HER2 status, were assessed. Results: The median follow-up period was 62 months. The 5-year second IBTR-free survival rate was 83%. Patients with the ER-positive/HER2-negative subtype of IBTR had a significantly better second IBTR-free survival rate than those with other subtypes of IBTR (88% vs. 75%, respectively, p= 0.02). Multivariate analysis revealed that the breast cancer subtype of IBTR was a significantly independent predictive factor of second IBTR-free survival (p= 0.003). A low-risk group for second IBTR, defined by the breast cancer subtype of IBTR and margin status of primary surgery, was detected (5-year second IBTR-free survival rate: 100%). Conclusion: Patients in the low-risk group defined by the breast cancer subtype of IBTR and margin status of primary surgery could safely undergo repeat lumpectomy without radiotherapy for IBTR.
机译：背景：患者患者的局部复发风险很少有没有放射治疗的患者的患者的局部复发肿瘤术后同侧乳腺肿瘤复发（IBTR）。患者及方法：在回顾性分析IBTR后，六十五名在没有放射治疗的情况下进行重复肿块切除术。评估了第二IBTR的危险因素，包括雌激素受体（ER）和HER2状态定义的IBTR的乳腺癌亚型。结果：中位随访期为62个月。 5年的IBTR免生存率为83％。 IBTR的ER阳性/ HER2阴性亚型的患者具有比IBTR的其他亚型（88％与75％，分别为P = 0.02）的更好的第二个IBTR的存活率。多变量分析显示，IBTR的乳腺癌亚型是第二IBTR的存活率明显独立的预测因子（P = 0.003）。检测到由IBTR乳腺癌亚型定义的第二IBTR的低风险组，并检测到初级手术的保证金状态（5年度IBTR的存活率：100％）。结论：在IBTR乳腺癌亚型定义的低风险组中的患者及初级手术的保证金状态可以安全地进行重复的肿块切除术，没有IBTR的放疗。

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