Multiple Copies of qnrA1 on an IncA/C-2 Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant

Vinue Laura; Sater Mohamad R. A.; Herriott Ian; Huntley Miriam H.; Jacoby George A.; Hooper David C.

首页> 外文期刊>Antimicrobial agents and chemotherapy. >Multiple Copies of qnrA1 on an IncA/C-2 Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant

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Multiple Copies of qnrA1 on an IncA/C-2 Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant

机译：INCA / C-2质粒上的QNRA1的多个拷贝解释了大肠杆菌突变体中增强的喹啉抗性

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In a previous study, mutants with enhanced ciprofloxacin resistance (Cip(r)) were selected from Escherichia coli J53/pMG252 carrying qnrA1. Strain J53 Cip(r) 8-2 showed an increase in the copy number and transcription level of qnrA1. We sequenced the plasmids on Illumina and MinION platforms. Parental plasmid pMG252 and plasmid pMG252A from strain J53 Cipr 8-2 were almost identical, except for the region containing qnrA1 that in pMG252A contained 4 additional copies of the qnrA1-qacE Delta 1-sull-ISCR1 region.

机译：在先前的研究中，从携带QNRA1的大肠杆菌J53 / PMG252中选择具有增强的环丙沙星抗性的突变体（CIP（R））。菌株J53 CIP（R）8-2显示QNRA1的拷贝数和转录水平的增加。我们测序了Illumina和矿物平台上的质粒。除菌株J53 CIPR 8-2中的父母质粒pMG252和质粒PMG252a几乎相同，除了含有qnra1的区域，在PMG252a中含有4个QNra1-qace delta 1-sull-iscr1区域的另外的副本。

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来源
《Antimicrobial agents and chemotherapy.》 |2019年第8期|共1页
作者
Vinue Laura; Sater Mohamad R. A.; Herriott Ian; Huntley Miriam H.; Jacoby George A.; Hooper David C.;
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作者单位

Massachusetts Gen Hosp Boston MA 02114 USA;

Day Zero Diagnost Boston MA USA;

Day Zero Diagnost Boston MA USA;

Day Zero Diagnost Boston MA USA;

Lahey Hosp &

Med Ctr Burlington MA USA;

Massachusetts Gen Hosp Boston MA 02114 USA;

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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
A/C-2 plasmid; Escherichia coil; ISCR1; ciprofloxacin; qnrA1;

机译：A / C-2质粒;大肠杆菌;ISCR1;CIPROFLOXACIN;QNRA1;

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专利

1. Multiple Copies of qnrA1 on an IncA/C-2 Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant [J] . Vinue Laura, Sater Mohamad R. A., Herriott Ian, Antimicrobial agents and chemotherapy. . 2019,第8期

机译：INCA / C-2质粒上的QNRA1的多个拷贝解释了大肠杆菌突变体中增强的喹啉抗性
2. Transfer of quinolone resistance gene qnrA1 to Escherichia coli through a 50 kb conjugative plasmid resulting from the splitting of a 300 kb plasmid [J] . Garza-RamosU., BarriosH., Hernandez-VargasM.J., The Journal of Antimicrobial Chemotherapy . 2012,第7期

机译：喹诺酮抗性基因qnrA1通过50 kb结合质粒转移到大肠杆菌中，该质粒是由300 kb质粒的分裂产生的
3. Plasmid-mediated quinolone resistance in Escherichia coli isolates from commercial broiler chickens and selection of fluoroquinolone-resistant mutants [J] . Nishikawa Ryo, Murase Toshiyuki, Ozaki Hiroichi Poultry Science . 2019,第11期

机译：质粒介导的大肠杆菌喹硫胺抗性来自商用肉鸡鸡的分离物和含氟喹啉龙突变体的选择
4. Multiple Stress Resistance in Pressure Resistant Escherichia coli Mutants [C] . K. Hauben, T. Nystrom, A. Farewell, International conference on high pressure bioscience and biotechnology . 1999

机译：耐压大肠杆菌突变体中的多重应力阻力
5. Development of low-copy expression vectors derived from the F plasmid of Escherichia coli. [D] . Jones, Kristala Lanett. 1999

机译：衍生自大肠杆菌F质粒的低拷贝表达载体的开发。
6. Multiple Copies of qnrA1 on an IncA/C2 Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant [O] . Laura Vinué, Mohamad R. A. Sater, Ian Herriott, 2019

机译：IncA / C2质粒上的qnrA1的多个副本解释了大肠杆菌突变体中增强的喹诺酮抗性。
7. Comparative genomics of multidrug resistance-encoding IncA/C plasmids from commensal and pathogenic Escherichia coli from multiple animal sources. [O] . Claudia Fernández-Alarcón, Randall S Singer, Timothy J Johnson 2011

机译：来自多种动物来源的共生和致病性大肠杆菌的多药抗性编码Inca / C质粒的比较基因组学。

Multiple Copies of qnrA1 on an IncA/C-2 Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant

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