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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Patient-to-Patient Transmission of Acinetobacter baumannii Gastrointestinal Colonization in the Intensive Care Unit
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Patient-to-Patient Transmission of Acinetobacter baumannii Gastrointestinal Colonization in the Intensive Care Unit

机译：重症监护单元中患者患者对患者的患者患者传播胃肠杆菌

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摘要

Acinetobacter baumannii is an important nosocomial pathogen. The objective of this study was to determine the proportion of A. baumannii infections due to patient-to-patient transmission by analyzing the molecular epidemiology of patients who acquired A. baumannii, using perianal surveillance cultures in a large 2-year intensive care unit (ICU) population. The design was a prospective cohort study. Patients who were admitted to the medical and surgical intensive care units at the University of Maryland Medical Center from 2011 to 2013 underwent admission, weekly, and discharge perianal culture collection. Using multilocus sequence typing (MLST) with subsequent pulsed-field gel electrophoresis (PFGE) for increased discrimination, combined with hospital overlap, the number of patients that acquired A. baumannii due to patient-to-patient transmission was determined. Our cohort consisted of 3,452 patients. In total, 196 cohort patients were colonized with A. baumannii; 130 patients were positive at ICU admission, and 66 patients acquired A. baumannii during their stay. Among the 196 A. baumannii patient isolates, there were 91 unique MLST types. Among the 66 patients who acquired A. baumannii, 31 (50%) were considered genetically related by MLST and/or PFGE type, and 11 (17%) were considered patient-to-patient transmission by genetic relatedness and overlapping hospital stay. Our data show that, of those cases of A. baumannii acquisition, at least 17% were cases of patient-to-patient transmission.
机译：AcineTobacter Baumannii是一个重要的医院病原体。本研究的目的是通过分析在大型2年重症监护室（ ICU）人口。该设计是一项潜在的队列研究。 2011年至2013年从2011年到2013年接受了Medich Medical Center大学的医疗和手术重症监护患者的患者接受了入学，每周和排放围场文化集合。使用随后脉冲场凝胶电泳（PFGE）的多层序列键入（MLST）用于增加鉴别，与医院重叠相结合，确定由于患者对患者传输而获得的A.Baumannii的患者的数量。我们的队列由3,452名患者组成。总共，196名群组患者与A. Baumannii殖民; 130名患者在ICU入院时阳性，66名患者在入住期间收购了A. Baumannii。在196 A.Baumannii患者分离物中，有91种独特的MLST类型。在66名获得A.Baumannii的患者中，通过MLST和/或PFGE型转入基因相关的31例（50％），并通过遗传相关性和重叠住院入住，11（17％）被认为是患者对患者的传播。我们的数据表明，在那些A.Baumannii收购的情况下，至少17％的患者对患者传播情况。

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